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Article
Open AccessMulti-Trait Body Shape Phenotypes and Breast Cancer Risk in Postmenopausal Women: A Causal Mediation Analysis in the UK Biobank Cohort
Body shape phenotypes combining multiple anthropometric traits have been linked to postmenopausal breast cancer (BC). However, underlying biological pathways remain poorly understood. This study investigated t...
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Article
Open AccessLarge-scale assessment of physical activity in a population using high-resolution hip-worn accelerometry: the German National Cohort (NAKO)
Large population-based cohort studies utilizing device-based measures of physical activity are crucial to close important research gaps regarding the potential protective effects of physical activity on chroni...
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Article
Author Correction: Suicide risk and mortality among patients with cancer
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Article
Open AccessCannabis use and the risk of primary open-angle glaucoma: a Mendelian randomization study
Several observational studies have investigated the association between cannabis use and intraocular pressure, but its association with primary open-angle glaucoma (POAG) remains unclear. In this study, we lev...
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Article
Open AccessAssociation between circadian physical activity patterns and mortality in the UK Biobank
The benefit of physical activity (PA) for increasing longevity is well-established, however, the impact of diurnal timing of PA on mortality remains poorly understood. We aimed to derive circadian PA patterns ...
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Article
Open AccessPhysical activity and the risk of periodontitis: an instrumental variable study
Observational studies suggested an inverse association between physical activity and periodontitis. However, observational studies might be subject to unobserved confounding and reverse causation bias. We cond...
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Article
Open AccessBody shape phenotypes of multiple anthropometric traits and cancer risk: a multi-national cohort study
Classical anthropometric traits may fail to fully represent the relationship of weight, adiposity, and height with cancer risk. We investigated the associations of body shape phenotypes with the risk of overal...
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Article
Open AccessHost genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota
Despite the increasing knowledge about factors sha** the human microbiome, the host genetic factors that modulate the skin-microbiome interactions are still largely understudied. This contrasts with recent e...
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Article
Open AccessSedentary behavior and cancer–an umbrella review and meta-analysis
Several systematic reviews and meta-analyses have summarized the association between sedentary behavior (SB) and cancer. However, the level of evidence and the potential for risk of bias remains unclear. This ...
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Article
Suicide risk and mortality among patients with cancer
Despite substantial progress in cancer therapy in recent decades, patients with cancer remain at high suicide risk. Data from individual studies have not been comprehensively quantified and specific risk facto...
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Article
Open AccessRare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4
Previous genome-wide association studies revealed multiple common variants involved in eczema but the role of rare variants remains to be elucidated. Here, we investigate the role of rare variants in eczema su...
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Article
Open AccessPhysical activity, sedentary behavior and risk of coronary artery disease, myocardial infarction and ischemic stroke: a two-sample Mendelian randomization study
Observational evidence suggests that physical activity (PA) is inversely and sedentarism positively related with cardiovascular disease risk. We performed a two-sample Mendelian randomization (MR) analysis to ...
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Article
Open AccessPeriodontitis and pulmonary function: a Mendelian randomization study
Observational research suggests that periodontitis affects pulmonary function; however, observational studies are subject to confounding and reverse causation, making causal inference and the direction of thes...
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Article
Open AccessAssociation between physical activity, grip strength and sedentary behaviour with incidence of malignant melanoma: results from the UK Biobank
Physical activity has been positively related to malignant melanoma. However, that association may be confounded by ultraviolet radiation (UV), a variable closely related to both outdoor physical activity and ...
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Article
Open AccessHäufigkeit von Asthma bronchiale und Alter bei der Erstdiagnose – erste Ergebnisse der NAKO Gesundheitsstudie
Asthma bronchiale stellt über alle Bildungsschichten hinweg eine der häufigsten chronischen Erkrankungen im Kindes- und Erwachsenenalter dar. Im Erwachsenenalter erstmals auftretendes Asthma (Adult-onset Asthm...
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Article
Open AccessAnthropometrische Messungen in der NAKO Gesundheitsstudie – mehr als nur Größe und Gewicht
Übergewicht und Adipositas sind bedeutende Risikofaktoren für verschiedene Erkrankungen. Als Maß zu ihrer Bestimmung wurde in früheren Studien meist nur der Body-Mass-Index (BMI) verwendet. Der BMI ist allerdi...
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Article
Körperliche Aktivität in der NAKO Gesundheitsstudie: erste Ergebnisse des multimodalen Erhebungskonzepts
Die körperliche Aktivität stellt ein komplexes Verhalten dar, dessen valide und reliable Erfassung in groß angelegten populationsbasierten Studien mit besonderen Herausforderungen einhergeht. In der bundesweit...
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Article
Open AccessThe metabolic network coherence of human transcriptomes is associated with genetic variation at the cadherin 18 locus
Metabolic coherence (MC) is a network-based approach to dimensionality reduction that can be used, for example, to interpret the joint expression of genes linked to human metabolism. Computationally, the deriv...
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Article
Author Correction: Genome-wide association and HLA fine-map** studies identify risk loci and genetic pathways underlying allergic rhinitis
In the version of this article initially published, in Fig. 3, the y-axis numbering did not match the log scale indicated in the axis label. The error has been corrected in the HTML and PDF version of the article...
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Article
Genome-wide association and HLA fine-map** studies identify risk loci and genetic pathways underlying allergic rhinitis
Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and unde...
