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    Circular DNA is a product of the immunoglobulin class switch rearrangement

    THE class of immunoglobulin is defined by the constant region of its heavy chain. When a B lymphocyte switches the class of heavy chain it produces, the constant region of µ-type heavy chain is replaced (reviewed...

    Uta von Schwedler, Hans-Martin Jck, Matthias Wabl in Nature (1990)