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Article
Open AccessExploring the landscape of Babesia bovis vaccines: progress, challenges, and opportunities
Bovine babesiosis, caused by different Babesia spp. such as B. bovis, B. bigemina, B. divergens, and B. major, is a global disease that poses a serious threat to livestock production. Babesia bovis infections are...
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Article
Open AccessThe role of MHC genes in contagious cancer: the story of Tasmanian devils
The Tasmanian devil, a marsupial species endemic to the island of Tasmania, harbours two contagious cancers, Devil Facial Tumour 1 (DFT1) and Devil Facial Tumour 2 (DFT2). These cancers pass between individual...
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Article
Erratum to: Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development
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Article
Open AccessThe tammar wallaby major histocompatibility complex shows evidence of past genomic instability
The major histocompatibility complex (MHC) is a group of genes with a variety of roles in the innate and adaptive immune responses. MHC genes form a genetically linked cluster in eutherian mammals, an organiza...
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Article
Open AccessGenome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development
We present the genome sequence of the tammar wallaby, Macropus eugenii, which is a member of the kangaroo family and the first representative of the iconic hop** mammals that symbolize Australia to be sequenced...
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The Marsupial Major Histocompatibility Complex
The major histocompatibility complex (MHC) contains genes that play essential roles in the innate and adaptive immune responses, and has been one of the most studied genomic regions among vertebrates. The mars...
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Article
Open AccessMHC-linked and un-linked class I genes in the wallaby
MHC class I antigens are encoded by a rapidly evolving gene family comprising classical and non-classical genes that are found in all vertebrates and involved in diverse immune functions. However, there is a f...
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Article
High levels of genetic variation at MHC class II DBB loci in the tammar wallaby (Macropus eugenii)
High levels of MHC diversity are crucial for immunological fitness of populations, with island populations particularly susceptible to loss of genetic diversity. In this study, the level of MHC class II DBB di...
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Article
The Immune Response of the Tasmanian Devil (Sarcophilus harrisii) and Devil Facial Tumour Disease
One of the most remarkable aspects of Devil Facial Tumour Disease (DFTD) is its infectious nature, and for successful transmission it must avoid detection by the devil’s immune system. For this to occur, the d...
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Article
Characterization of major histocompatibility complex class I and class II genes from the Tasmanian devil (Sarcophilus harrisii)
The Tasmanian devil (Sarcophilus harrisii) is currently threatened by an emerging wildlife disease, devil facial tumour disease. The disease is decreasing devil numbers dramatically and may lead to the extinction...
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Article
Isolation of major histocompatibility complex Class I genes from the tammar wallaby (Macropus eugenii)
The major histocompatibility complex (MHC) plays an essential role in the adaptive immune system of vertebrates through antigen recognition. Although MHC genes are found in all vertebrates, the MHC region is d...
