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Protocol
Early Cancer Biomarker Discovery Using DIA-MS Proteomic Analysis of EVs from Peripheral Blood
One of the cornerstones of effective cancer treatment is early diagnosis. In this context, the identification of proteins that can serve as cancer biomarkers in bodily fluids (“liquid biopsies”) has gained att...
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Article
Extracellular vesicle proteomes of two transmissible cancers of Tasmanian devils reveal tenascin-C as a serum-based differential diagnostic biomarker
The iconic Tasmanian devil (Sarcophilus harrisii) is endangered due to the transmissible cancer Devil Facial Tumour Disease (DFTD), of which there are two genetically independent subtypes (DFT1 and DFT2). While D...
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Article
NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in transmissible cancers
Downregulation of MHC class I (MHC-I) is a common immune evasion strategy of many cancers. Similarly, two allogeneic clonal transmissible cancers have killed thousands of wild Tasmanian devils (Sarcophilus harris...
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Article
Curse of the devil: molecular insights into the emergence of transmissible cancers in the Tasmanian devil (Sarcophilus harrisii)
The Tasmanian devil (Sarcophilus harrisii) is the only mammalian species known to be affected by multiple transmissible cancers. Devil facial tumours 1 and 2 (DFT1 and DFT2) are independent neoplastic cell lineag...
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Article
Two of a kind: transmissible Schwann cell cancers in the endangered Tasmanian devil (Sarcophilus harrisii)
Devil facial tumour disease (DFTD) comprises two genetically distinct transmissible cancers (DFT1 and DFT2) endangering the survival of the Tasmanian devil (Sarcophilus harrisii) in the wild. DFT1 first arose fro...
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Article
Open AccessGomesin peptides prevent proliferation and lead to the cell death of devil facial tumour disease cells
The Tasmanian devil faces extinction due to devil facial tumour disease (DFTD), a highly transmittable clonal form of cancer without available treatment. In this study, we report the cell-autonomous antiprolif...
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Article
Open AccessRegression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils
Devil facial tumour disease (DFTD) is a transmissible cancer devastating the Tasmanian devil (Sarcophilus harrisii) population. The cancer cell is the ‘infectious’ agent transmitted as an allograft by biting. Ani...
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Chapter
Ultraviolet Radiation Effects on the Proteome of Skin Cells
Proteomic studies to date have had limited use as an investigative tool in the skin’s response to UV radiation. These studies used cell lines and reconstructed skin and have shown evidence of cell injury with ...
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Article
UV-induced immunosuppression and the efficacy of vaccination
Exposure to ultraviolet radiation (UVR) suppresses immunity by complex pathways, initiated by chromophores located in the skin and ending with the generation of specific subsets of T and B regulatory cells. Th...
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Article
The two faces of metallothionein in carcinogenesis: photoprotection against UVR-induced cancer and promotion of tumour survival
Metallothionein is a multi-functional protein that protects the host against toxic heavy metals. Under stressful situations it can protect against oxidative damage, contribute to tissue repair, modulate immune...
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Article
Solar simulated ultraviolet radiation damages murine neonatal skin and alters Langerhans cell development, but does not induce inflammation
Development of melanoma has been linked to excessive childhood exposure to sunlight. As neonates have a relatively underdeveloped immune system, it is likely that the immune system reacts differently to the ex...
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Article
The Immune Response of the Tasmanian Devil (Sarcophilus harrisii) and Devil Facial Tumour Disease
One of the most remarkable aspects of Devil Facial Tumour Disease (DFTD) is its infectious nature, and for successful transmission it must avoid detection by the devil’s immune system. For this to occur, the d...
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Chapter
Dendritic Cells, Apoptosis and Murine Retrovirus
Apoptosis is a universal form of “programmed” cell death that appears to have a key role in the development and regulation of the immune system1. Induction of the apoptotic pathway is a complex event, but in m...
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Chapter
Dendritic Cells Migrating from Carcinogen-Treated Skin Have Reduced Antigen-Presenting Function
Chemical carcinogens have a recognised ability to reduce the status of cutaneous immunity. Antigen presentation through carcinogen-treated skin results in immune suppression rather than activation of effector ...
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Chapter
Depletion of Langerhans Cells Following Carcinogen Treatment is Partly Due to Antigenicity
Langerhans cells (LC) are skin dendritic cells that trap foreign antigens1 and migrate to the local lymph nodes where they present antigen to initiate an immune response. Maintenance of LC density is an essential...
