7 Result(s)
within
Hamid Kashkar
English
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessCD4+ T cell-induced inflammatory cell death controls immune-evasive tumours
Most clinically applied cancer immunotherapies rely on the ability of CD8+ cytolytic T cells to directly recognize and kill tumour cells1–3. These strategies are limited by the emergence of major histocompatibili...
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Article
Open AccessATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers
Mucosal and skin cancers are associated with infections by human papillomaviruses (HPV). The manner how viral oncoproteins hijack the host cell metabolism to meet their own energy demands and how this may cont...
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Article
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
Caspase-8 is the initiator caspase of extrinsic apoptosis1,2 and inhibits necroptosis mediated by RIPK3 and MLKL. Accordingly, caspase-8 deficiency in mice causes embryonic lethality3, which can be rescued by del...
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Article
Open AccessCorticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition
Corticosteroids are host-directed drugs with proven beneficial effect on survival of tuberculosis (TB) patients, but their precise mechanisms of action in this disease remain largely unknown. Here we show that...
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Article
Open AccessErratum: Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
Nature Communications 7: Article number: 10612 (2016); Published: 4 February 2016; Updated: 17 May 2016. This Article contains errors in the labelling of Fig. 5 and Supplementary Fig. 6, the former of which wa...
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Article
Open AccessChromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
The coordinated activity of DNA replication factors is a highly dynamic process that involves ubiquitin-dependent regulation. In this context, the ubiquitin-directed ATPase CDC-48/p97 recently emerged as a key...
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Article
Riboflavin kinase couples TNF receptor 1 to NADPH oxidase
Riboflavin kinase has been identified as a novel interacting partner for the death domain of receptor-1 for tumour necrosis factor (TNF-R1). It is required to recruit to and functionally couple p22phox to TNF-R1....
