-
Article
Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice
Mice lacking genes involving in the DNA-damage response (DDR) are often tumor prone owing to genome instability caused by oncogenic challenges. Previous studies demonstrate that activating transcription factor...
-
Article
Epithelial–mesenchymal transition of ovarian cancer cells is sustained by Rac1 through simultaneous activation of MEK1/2 and Src signaling pathways
Epithelial–mesenchymal transition (EMT) is regarded as a crucial contributing factor to cancer progression. Diverse factors have been identified as potent EMT inducers in ovarian cancer. However, molecular mec...
-
Article
Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5+CK8+ epithelial cells
Steroid sex hormones can induce prostate carcinogenesis, and are thought to contribute to the development of prostate cancer during aging. However, the mechanism for hormone-induced prostate carcinogenesis rem...
-
Article
Open AccessUnveiling the Mechanism for the Split Hysteresis Loop in Epitaxial Co2Fe1-xMnxAl Full-Heusler Alloy Films
Utilizing epitaxial Co2Fe1-xMnxAl full-Heusler alloy films on GaAs (001), we address the controversy over the analysis for the split hysteresis loop which is commonly found in systems consisting of both uniaxial ...
-
Article
Loss of ATF3 promotes Akt activation and prostate cancer development in a Pten knockout mouse model
Activating transcription factor 3 (ATF3) responds to diverse cellular stresses, and regulates oncogenic activities (for example, proliferation, survival and migration) through direct transcriptional regulation...
-
Article
Open AccessSpectroscopic study of Gd nanostructures quantum confined in Fe corrals
Low dimensional nanostructures have attracted attention due to their rich physical properties and potential applications. The essential factor for their functionality is their electronic properties, which can ...
-
Chapter and Conference Paper
A Novel, Loop-Based Approach for Rigidity Detection for Systems with Multiple Spherical–Spherical Bars: The “Double-Banana” Case
Rigidity detection is a very important tool for structural synthesis of mechanisms and the processing of CAD-generated models, as it helps to unveil possible sources of inconsistency in Grübler’s count of degr...
-
Article
Open AccessMEIS2 is essential for neuroblastoma cell survival and proliferation by transcriptional control of M-phase progression
MEIS2 has an important role in development and organogenesis, and is implicated in the pathogenesis of human cancer. The molecular basis of MEIS2 action in tumorigenesis is not clear. Here, we show that MEIS2 ...
-
Article
Open AccessDirect effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation
Embryonal cancer can arise from postnatally persistent embryonal remnant or rest cells, which are uniquely characterized by the absence of p53 mutations. Perinatal overexpression of the MycN oncoprotein in emb...
-
Article
Interleukin enhancer-binding factor 3 promotes breast tumor progression by regulating sustained urokinase-type plasminogen activator expression
Sustained urokinase-type plasminogen activator (uPA) expression is detected in aggressive breast tumors. Although uPA can be transiently upregulated by diverse extracellular stimuli, sustained, but not transie...
-
Article
A Dual-Capacitors Type Energy Recovery Power System for Repetitive Pulsed High Magnetic Fields
As a flexible and convenient tool, a repetitive pulsed high magnetic field (RPHMF) would be employed for scientific research and industrial applications. A novel RPHMF system design adopting a dual-capacitors ...
-
Article
Test and Operation of the WHMFC 12.6 MJ Capacitor Bank Power Supply System
The 12.6 MJ capacitor bank power supply system of the Wuhan National High Magnetic Field Center (WHMFC) at Huazhong University of Science and Technology (HUST) consists of 11 independent 1 MJ modules and 2 ind...
-
Article
Design of a 60 T Quasi-continuous Magnetic Field System with a Hybrid Capacitor/Rectifier Power Supply
At the Wuhan National High Magnetic Field Center, a 135 MW rectifier power supply is being installed nearby a 11 MJ capacitor bank power supply. By combining the two power supplies, a 60 T / 100 ms quasi-conti...
-
Article
Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression
The Polycomb transcription repressor BMI1 is highly expressed in human neuroblastomas and is required for the clonogenic self-renewal and tumorigenicity of human neuroblastoma cell lines. The molecular basis o...
-
Article
Fine map** of a quantitative trait locus qHD3-1, controlling the heading date, to a 29.5-kb DNA fragment in rice
In our previous studies, a single segment substitution line (SSSL) W23-03-8-9-1 with substituted interval of PSM301-PSM306-PSM305-PSM304-RM3894-RM3372-RM569-RM231-RM545 on chromosome 3 has been found to compri...
-
Article
The New Developed Components Tests for 1 MJ Capacitor Power Supply System in Wuhan High Magnetic Field Facility
A new 1 MJ, 25 kV, 40 kA pulsed capacitor power supply system for the Wuhan High Magnetic Field Facility (WHMFF) has been achieved. The desire for 70 or higher tesla magnetic field to support a lot of scientif...
-
Article
Progress in the Development of the Wuhan High Magnetic Field Center
Since April 2008 the Wuhan High Magnetic Field Center (WHMFC) has been under development at the Huazhong University of Science and Technology (HUST) at Wuhan, China. It is funded by the Chinese National Develo...
-
Article
Delimitation of the fgr gene for rice fragrance to a 28-kb DNA fragment
The fragrance gene plays an important role in high-quality rice varieties and has been widely used in breeding programs. Using a random sample of 370 individuals from an F2 segregating population developed from a...
-
Article
High-resolution magnetic imaging by local tunneling magnetoresistance
We give an overview over our recent efforts of high-resolution magnetic imaging using scanning tunneling microscopy with a ferromagnetic tip. Magnetic sensitivity is obtained on the basis of local tunneling ma...
