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Article
Open AccessSingle- versus double-layer closure of the caesarean (uterine) scar in the prevention of gynaecological symptoms in relation to niche development – the 2Close study: a multicentre randomised controlled trial
Double-layer compared to single-layer closure of the uterus after a caesarean section (CS) leads to a thicker myometrial layer at the site of the CS scar, also called residual myometrium thickness (RMT). It po...
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Article
Open AccessDoes endometrial scratching increase the rate of spontaneous conception in couples with unexplained infertility and a good prognosis (Hunault > 30%)? Study protocol of the SCRaTCH-OFO trial: a randomized controlled trial
In the Netherlands, couples with unexplained infertility and a good prognosis to conceive spontaneously (i.e. Hunault > 30%) are advised to perform timed intercourse for at least another 6 months. If couples f...
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Article
Open AccessQuality of life of patients with chronic lymphocytic leukaemia in the Netherlands: results of a longitudinal multicentre study
To describe the health-related quality of life (HRQoL) of an unselected population of patients with chronic lymphocytic leukaemia (CLL) including untreated patients.
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Article
Open AccessThe likelihood of holding outdoor skating marathons in the Netherlands as a policy-relevant indicator of climate change
“When I was born – in 1956 – the chance of realizing a Frisian Eleven City Ice Skating Marathon in Netherlands was 1 in 4. When my daughter was born – in 1999 – this chance had diminished to 1 in 10. An enormo...
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Article
CLINICAL AND HORMONAL EVALUATION OF BOYS BORN WITH UNDESCENDED TESTES DURING THEIR FIRST YEAR OF LIFE
Forty-eight boys with uni- (n=40) or bilateral (n=8) cryptorchidism were followed during the first year of life with informed consent of the parents. 24 of them in study within the first 3 mo of life (<3 mo). ...
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Article
12 A DOUBLE BLIND PLACEBO CONTROLLED (dbpc) STUDY OF LHRH TREATMENT OP UNI-& BILATERAL CRYPTORCHIDISM
250 prepubertal boys were treated with LHRH nasal spray (HOE 471) 400 ug t.i.d.; 28 days in dbpc study. Whenever a 2nd Rx course proved unsuccessful after a 4wk interval, orchidopexy was performed.
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Article
Height prediction by a linear regression procedure
The currently used final height prediction methods are based on an estimate of the growth potential, which can be read from the Bayley-Pinneau tables once bone age (BA) and chronological age (CA) are known. Us...
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Article
Hydroxylated sterols and the human fetal adrenal
The conversion by isolated human fetal adrenal cells (24 wks gestation) of 25-OH-cholesterol (25-OH), 22S-OH-cholesterol (22S). 17,20-diOH-cholesterol(17,20) and 17-OH-pregnenolone(17-OH) into C21 and C19 steroid...