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    Article

    Pharmacokinetic, pharmacodynamic and intracellular effects of PEG-asparaginase in newly diagnosed childhood acute lymphoblastic leukemia: results from a single agent window study

    L-asparaginase is an effective drug for treatment of children with acute lymphoblastic leukemia (ALL). The effectiveness is thought to result from depletion of asparagine in serum and cells. We investigated the.....

    I M Appel, K M Kazemier, J Boos, C Lanvers, J Huijmans, A J P Veerman… in Leukemia (2008)

  2. Article

    Hydroxylated sterols and the human fetal adrenal

    The conversion by isolated human fetal adrenal cells (24 wks gestation) of 25-OH-cholesterol (25-OH), 22S-OH-cholesterol (22S). 17,20-diOH-cholesterol(17,20) and 17-OH-pregnenolone(17-OH) into C21 and C19 steroid...

    J Huijmans, H Degenhart, H Visser in Pediatric Research (1978)

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