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Article
Computer-Aided Skeletal Age Scores in Healthy Children, Girls with Turner Syndrome, and in Children with Constitutionally Tall Stature
The manual Tanner-Whitehouse 2 method has recently been transformed into a computer-aided skeletal age scoring system (CASAS), which rates either the complete TW-RUS score (13b model) or a subset consisting of...
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Article
EFFECT OF GROWTH HORMONE (GH) TREATMENT ON LEFT VENTRICULAR (LV) CARDIAC DIMENSIONS IN TURNER SYNDROME (TS)
Modest changes in bloodpressure (BP) and LV dimensions have been reported after only 1 yr GH-Rx on idiopathic short children (1). GH excess, as in acromegalic pts, may load to (e)symmetrical cardiac hypertroph...
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Article
TWO YEAR RESULTS OF GROWTH HORMONE THERAPY IN ADOLESCENTS WITH SHORT STATURE AFTER RENAL TRANSPLANTATION (RTx)
In a double-blind, 2-yr study, 16 pubortal patients with growth retardation after RTx were Iroatod with either Norditropin 4 (gr A) or 8 (gr B) IU/m2/day. We studied the effects of growth hormone therapy (GHRx) o...
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Article
TWO YEAR AUXOLOGICAL RESULTS OF A GROWTH HORMONE (GH) DOSE-RESPONSE STUDY IN TURNER SYNDROME (TS)
In a multicenter dose-response study, 68 girls with TS (Tanner stage B1), age 6.5 (2.3) yr (range 2.1-11.0 yr) were randomized into 3 groups according to CA and H-SDSCA: A (n=23) 4 IU hGH/m2 b.s. for 4 yr, B (n =...
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Article
CLINICAL AND HORMONAL EVALUATION OF BOYS BORN WITH UNDESCENDED TESTES DURING THEIR FIRST YEAR OF LIFE
Forty-eight boys with uni- (n=40) or bilateral (n=8) cryptorchidism were followed during the first year of life with informed consent of the parents. 24 of them in study within the first 3 mo of life (<3 mo). ...
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Article
12 A DOUBLE BLIND PLACEBO CONTROLLED (dbpc) STUDY OF LHRH TREATMENT OP UNI-& BILATERAL CRYPTORCHIDISM
250 prepubertal boys were treated with LHRH nasal spray (HOE 471) 400 ug t.i.d.; 28 days in dbpc study. Whenever a 2nd Rx course proved unsuccessful after a 4wk interval, orchidopexy was performed.
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Article
Height prediction by a linear regression procedure
The currently used final height prediction methods are based on an estimate of the growth potential, which can be read from the Bayley-Pinneau tables once bone age (BA) and chronological age (CA) are known. Us...
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Article
In vitro studies of enzymatic activities in human adrenal tumours
In order to correlate in vitro enzyme activity with clinical data, several enzymes involved in adrenal steroidogenesis were determined in human adrenal tissue, obtained from patients undergoing adrenalectomy. ...