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Article
Voriconazole-induced QT prolongation among hemato-oncologic patients: clinical characteristics and risk factors
The purpose of this study is to determine the rate of QTcP and associated risk factors in patients treated with voriconazole.
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Article
Computer assisted design of a theophylline dosing regimen in acute bronchospasm: Serum concentrations and clinical outcome
The effect of intravenous theophylline on the outcome of inhospital treatment of acute bronchospasm has been assessed, comparing the results achieved by computer-assisted dosing, designed to achieve and mainta...
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Article
Elevated serum uric acid — a facet of hyperinsulinaemia
In a representative sample of the adult Jewish population in Israel (n=1016) excluding known diabetic patients and individuals on antihypertensive medications, serum uric acid showed a positive association with p...
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Article
Effect of past and concurrent body mass index on prevalence of glucose intolerance and Type 2 (non-insulin-dependent) diabetes and on insulin response
A representative sample (n=2140) of the Israeli Jewish population aged 40–70 (excluding known diabetic patients), whose body mass index had been measured 10 years earlier, underwent an oral glucose tolerance test...
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Article
Mechanism of warfarin potentiation by amiodarone: Dose — and concentration — Dependent inhibition of warfarin elimination
Potentiation of the anticoagulant-effect of warfarin by amiodarone was studied in 30 patients. Thirteen received both drugs concurrently, and 17 received warfarin alone and the combination sequentially. Warfar...
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Article
Components of variability in serum theophylline concentrations during maintenance therapy with a sustained release formulation
Fifteen adult chronic asthmatic patients were studied on 6 consecutive days of the second week of treatment with a new sustained release theophylline formulation, and 8 were again studied after three months on...
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Article
MATURATION OF RENAL TUBULAR TRANSPORT OF DIGOXIN
Previous data have suggested an age related increase in renal tubular secretion of digoxin in infants and children receiving long term digoxin therapy. This phenomenon could be the result of a maturational pro...
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Article
Once daily administration of sustained release propranolol capsules in the treatment of angina pectoris
The effect of once daily administration of sustained release capsules of propranolol 160 mg was compared with treatment with standard 40 mg tablets four times daily, in eight patients with stable angina pector...
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Article
Steady state serum concentrations and renal clearance of digoxin in neonates, infants and children
Steady state serum concentrations of digoxin were determined repeatedly in 34 infants with congenital heart disease. Simultaneous measurements of renal clearances of digoxin, creatinine and urea were obtained ...
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Article
A satisfactory treatment of equality and operator constraints in the Dubovitskii-Milyutin optimization formalism
The formalism of Dubovitskii and Milyutin is very attractive but, up to now, it could not be applied to optimization problems involving equality and operator constraints. In the present paper, the formalism of...
