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  1. No Access

    Article

    Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent

    There are many strains of the agents that cause transmissible spongiform encephalopathies (TSEs) or ‘prion’ diseases. These strains are distinguishable by their disease characteristics in experimentally infect...

    M. E. Bruce, R. G. Will, J. W. Ironside, I. McConnell, D. Drummond, A. Suttie… in Nature (1997)

  2. No Access

    Article

    Neuronal spread of scrapie agent and targeting of lesions within the retino-tectal pathway

    Scrapie is a transmissible encephalopathy of sheep and goats, and a number of mammalian species can be infected experimentally. Various strains of the transmissible agent are distinguishable on pathological an...

    H. Fraser in Nature (1982)

  3. No Access

    Article

    Mitogenic stimulation of the host enhances susceptibility to scrapie

    THERE are several reasons for concluding that scrapie agents depend, for extraneural replication, on some components of the host's lymphoreticular system being functional1. Agent replication occurs earliest in th...

    A. G. DICKINSON, H. FRASER, IRENE MCCONNELL, G. W. OUTRAM in Nature (1978)

  4. No Access

    Article

    Scrapie incubation time can exceed natural lifespan

    IN mice injected with mouse-passaged scrapie, the earliest rise in titre of agent is found in organs of the lymphoreticular system—irrespective of whether the injection is intracerebral or by a peripheral route1–...

    A. G. DICKINSON, H. FRASER, G. W. OUTRAM in Nature (1975)

  5. Article

    Extraneural competition between different scrapie agents leading to loss of infectivity

    MANY strains of scrapie agent have been isolated which differ in their biological properties, such as incubation period and type of brain lesion1. We have shown previously that competition occurred between differ...

    A. G. DICKINSON, H. FRASER, IRENE MCCONNELL, G. W. OUTRAM, D. I. SALES… in Nature (1975)

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  6. No Access

    Article

    Reduced susceptibility to scrapie in mice after steroid administration

    ANIMALS deficient in lymphoreticular function either by age, genotype or immunosuppression are more susceptible to infection by most known pathogens mainly on account of their depressed immunological responses...

    G. W. OUTRAM, A. G. DICKINSON, H. FRASER in Nature (1974)

  7. No Access

    Article

    Depression of polymorph counts by various scrapie agents

    IT has been reported by Carp, Licursi, Merz and Merz1,2 that the percentage of circulating polymorphonuclear neutrophils (PMN) in C57Bl mice was reduced permanently following injection with either multiple sclero...

    A. G. DICKINSON, D. M. TAYLOR, H. FRASER in Nature (1974)

  8. Article

    Developmental Maturation of Susceptibility to Scrapie in Mice

    AGE at the time of injection has not been shown to influence the incubation period of peripherally injected scrapie in mice over 6 days old1, although a slight negative regression from birth to four months has be...

    G. W. OUTRAM, A. G. DICKINSON, H. FRASER in Nature (1973)

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  9. No Access

    Article

    Pathogenesis of Scrapie in the Mouse: the Role of the Spleen

    IN mice experimentally inoculated with scrapie agent, some sites for the early increase in titre lie within lympho reticular tissues, particularly the spleen1,2. The time at which the agent can first be demonstra...

    H. FRASER, A. G. DICKINSON in Nature (1970)

  10. No Access

    Article

    Modification of the Pathogenesis of Scrapie in Mice by Treatment of the Agent

    Two major areas in scrapie research depend on estimates of the concentration of the agent: investigation of the nature of the agent by the effect of various chemical or physical treatments and of the pathogene...

    A. G. DICKINSON, H. FRASER in Nature (1969)

  11. No Access

    Article

    Distribution of Experimentally Induced Scrapie Lesions in the Brain

    LESIONS of scrapie are confined to the central nervous system. Differences in the distribution of these lesions have been described for the two strains of scrapie agent used in goats1 and for the lesions which ar...

    H. FRASER, A. G. DICKINSON in Nature (1967)