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Pathogenesis of Scrapie in the Mouse: the Role of the Spleen

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Abstract

IN mice experimentally inoculated with scrapie agent, some sites for the early increase in titre lie within lympho reticular tissues, particularly the spleen1,2. The time at which the agent can first be demonstrated to have increased in amount in the spleen depends on the host genotype2 and also, probably, on other factors such as dose and strain of agent, which influence the overall time course of the disease3,4. The incubation period after intracerebral inoculation of ME 7 scrapie agent prepared as a saline homogenate of infected brain is about two-thirds of that for an equivalent dose by the intraperitoneal route5. Further, after intracerebral inoculation, levels in the spleen rise marginally earlier than they do following intraperitoneal inoculation2.

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References

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Authors and Affiliations

  1. Moredun Research Institute, Gilmerton, Edinburgh

    H. FRASER

  2. ARC Animal Breeding Research Organization, Edinburgh

    A. G. DICKINSON

Authors
  1. H. FRASER
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  2. A. G. DICKINSON
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FRASER, H., DICKINSON, A. Pathogenesis of Scrapie in the Mouse: the Role of the Spleen. Nature 226, 462–463 (1970). https://doi.org/10.1038/226462a0

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  • DOI: https://doi.org/10.1038/226462a0

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