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Article
An Ice Age JWST inventory of dense molecular cloud ices
Icy grain mantles are the main reservoir of the volatile elements that link chemical processes in dark, interstellar clouds with the formation of planets and the composition of their atmospheres. The initial i...
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Article
Detailed Investigation of Core–Shell Precipitates in a Cu-Containing High Entropy Alloy
Due to the competing influences of configurational entropy and enthalpy of mixing, in recent years, secondary (including intermetallic) phases have been reported in many high entropy alloy (HEA) systems. These...
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Article
A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair
Thoraco-abdominal aneurysms (TAAA) represents a particularly lethal vascular disease that without surgical repair carries a dismal prognosis. However, there is an inherent risk from surgical repair of spinal c...
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Article
Occurrence, genetic diversity, and potential pathways of entry of Halyomorpha halys in newly invaded areas of Canada and Switzerland
Halyomorpha halys has recently established in countries outside of its Asian area of origin. In the North Eastern USA, this pest causes severe economic loss in agricultural crops. Breeding popula...
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Article
Predictive value of abdominal obesity cut-off points for hypertension in Blacks from West African and Caribbean island nations
BACKGROUND: Waist circumferences (WC) ≥94 cm for men and ≥80 cm for women (action level I) and ≥102 cm for men and ≥88 cm for women (action level II) have been suggested as limits for health promotion purposes...
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Chapter
Follicular dendritic cells in scrapie pathogenesis
Scrapie pathogenesis was studied in chimaeric mice that carried the prion protein (PrP) gene only in particular cells of the immune system. These mice were produced by grafting bone marrow from PrP expressing ...
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Article
Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells
The immune system is central in the pathogenesis of scrapie and other transmissible spongiform encephalopathies (TSEs) or 'prion' diseases1. After infecting by peripheral (intraperitoneal or oral) routes, most TS...
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Article
Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent
There are many strains of the agents that cause transmissible spongiform encephalopathies (TSEs) or ‘prion’ diseases. These strains are distinguishable by their disease characteristics in experimentally infect...
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Article
Decontamination studies with the agents of bovine spongiform encephalopathy and scrapie
Macerates of bovine brain infected with bovine spongiform encephalopathy (BSE) agent, and rodent brain infected with the 263K or ME7 strains of scrapie agent, were subjected to porous-load autoclaving at tempe...
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Article
Ultrastructural features of spongiform encephalopathy transmitted to mice from three species of bovidae
The ultrastructural neuropathology of mice experimentally inoculated with brain tissue of nyala (Tragelaphus angasi; subfamily Bovinae), or kudu (Tragelaphus strepsiceros; subfamily Bovinae) affected with spongif...
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Article
Cerebral amyloid plaques in Alzheimer’s disease but not in scrapie-affected mice are closely associated with a local inflammatory process
Complement proteins of the classical pathway can be immunohistochemically identified in cerebral amyloid plaques in Alzheimer’s disease. Microglial cells in and around amyloid plaques express class II major hi...
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Article
Scrapie inoculation of mice: light and electron microscopy of the superior colliculi
Ultrastructural examination of the superior colliculi of mice intraocularly inoculated with the ME7 strain of scrapie showed vacuolation early in the course of infection. Brains were examined between 85–260 da...
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Chapter
Scrapie Strain Variation and Its Implications
Strain variation in scrapie was first recognised about 30 years ago, when experimental sheep scrapie was transmitted to and serially passaged in goats. Two separate passage lines were maintained which produced...
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Chapter and Conference Paper
The Blood-Brain Barrier in Cerebral Amyloidogenesis in Alzheimer’s Disease and Scrapie
There is a diversity of opinions concerning the defect in the blood-brain barrier permeability in Alzheimer’s disease and in scrapie. In this paper we review the evidence for blood-brain barrier dysfunction an...
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Article
No evidence for involvement of plasma proteins or blood-borne cells in amyloid plaque formation in scrapie-affected mice
The present study was designed to investigate blood-brain permeability and the possible involvement of plasma proteins and blood-borne cells in amyloid plaque formation in scrapie-affected mice. No abnormal ex...
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Article
Driving force for discontinuous coarsening in a Ni-Al-Mo base superalloy
The driving force and mechanism for discontinuous coarsening (DC) in a Ni-Al-Mo base superalloy were studied. Samples were solutionized at 1300 °C, cooled, and aged at 1150 °C to produce DC. Both the intragran...
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Chapter and Conference Paper
Parallels and Contrasts Between Scrapie and Dementia of the Alzheimer Type and Ageing: Strategies and Problems for Experiments Involving Life Span Studies
Scrapie is a naturally occurring, lethal degeneration of the nervous system of adult sheep, caused by an unconventional, virus-like agent the nature of which has yet to be resolved. Recently, several parallels...
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Article
Degenerative hippocampal pathology in mice infected with scrapie
The lesions of scrapie are confined to the CNS, and the most characteristic histopathological change in mice terminally infected with scrapie is vacuolation. With most laboratory strains of scrapie, one of the...
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Article
Focal and asymmetrical vacuolar lesions in the brains of mice infected with certain strains of scrapie
In mice experimentally infected with most strains of scrapie, vacuolar degeneration almost always shows a bilaterally symmetrical distribution in the brain. However, asymmetrical foci of vacuolation are freque...
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Article
Neuronal spread of scrapie agent and targeting of lesions within the retino-tectal pathway
Scrapie is a transmissible encephalopathy of sheep and goats, and a number of mammalian species can be infected experimentally. Various strains of the transmissible agent are distinguishable on pathological an...
