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A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair

  • Non-invasive Diagnostic Systems
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Abstract

Thoraco-abdominal aneurysms (TAAA) represents a particularly lethal vascular disease that without surgical repair carries a dismal prognosis. However, there is an inherent risk from surgical repair of spinal cord ischaemia that can result in paraplegia. One method of reducing this risk is cerebrospinal fluid (CSF) drainage. We believe that the CSF contains clinically significant biomarkers that can indicate impending spinal cord ischaemia. This work therefore presents a novel measurement method for proteins, namely albumin, as a precursor to further work in this area. The work uses an interdigitated electrode (IDE) sensor and shows that it is capable of detecting various concentrations of albumin (from 0 to 100 g/L) with a high degree of repeatability at 200 MHz (R2 = 0.991) and 4 GHz (R2 = 0.975).

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Authors and Affiliations

  1. Thoracic Aortic Aneurysm Service, Liverpool Heart & Chest Hospital, Thomas Drive, L14 3PE, Liverpool, Merseyside, UK

    M. Fok, M. Bashir, H. Fraser, N. Strouther & A. Mason

  2. Liverpool John Moores University, Built Environment and Sustainable Technologies (BEST) Research Institute, RF and Microwave Research Group, Henry Cotton Building, 15-21 Webster Street, Liverpool, L3 2ET, UK

    M. Fok

Authors
  1. M. Fok
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  2. M. Bashir
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  3. H. Fraser
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  4. N. Strouther
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  5. A. Mason
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Correspondence to A. Mason.

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This article is part of the Topical Collection on Patient Facing Systems

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Fok, M., Bashir, M., Fraser, H. et al. A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair. J Med Syst 39, 37 (2015). https://doi.org/10.1007/s10916-015-0208-4

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  • DOI: https://doi.org/10.1007/s10916-015-0208-4

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