31 Result(s)

Reference Work Entry In depth

Progression of Chronic Kidney Disease and Nephroprotection in Children

Progression of chronic kidney disease (CKD) towards kidney replacement therapy is inevitable in some CKD patients and once significant impairment of kidney function has occurred it tends to progress almost irr...

Elke Wühl, H. William Schnaper in Pediatric Nephrology (2022)

Living Reference Work Entry In depth

Progression of Chronic Kidney Disease and Nephroprotection in Children

Progression of chronic kidney disease (CKD) towards kidney replacement therapy is inevitable in some CKD patients and once significant impairment of kidney function has occurred it tends to progress almost irr...

Elke Wühl, H. William Schnaper in Pediatric Nephrology

Reference Work Entry In depth

Pathophysiology of Progressive Renal Disease in Children

Chronic kidney disease (CKD) is a condition in which an initial injury is superseded by a more gradual, chronic process of decreasing function that, in the most extreme cases, ultimately leads to the need for ...

H. William Schnaper in Pediatric Nephrology (2016)

Article

Defining new surrogate markers for CKD progression

At a recent meeting of international experts on clinical aspects of progressive chronic kidney disease (CKD), an extensive analysis of extant clinical trials was used to develop more effective and economical s...

H. William Schnaper, Susan L. Furth, Lynne P. Yao in Pediatric Nephrology (2015)

Article

Tubulointerstitial injury and the progression of chronic kidney disease

In chronic kidney disease (CKD), once injury from any number of disease processes reaches a threshold, there follows an apparently irreversible course toward decline in kidney function. The tubulointerstitium ...

Kavita S. Hodgkins, H. William Schnaper in Pediatric Nephrology (2012)

Article

A conceptual framework for the molecular pathogenesis of progressive kidney disease

The data regarding the pathogenesis of progressive kidney disease implicate cytokine effects, physiological factors, and myriad examples of relatively nonspecific cellular dysfunction. The sheer volume of info...

H. William Schnaper, Susan C. Hubchak, Constance E. Runyan… in Pediatric Nephrology (2010)

Reference Work Entry In depth

Pediatric Nephrology Around the World – North America

Pediatric nephrologists in North America care for children who have a wide variety of acute and chronic kidney diseases. Two registries provide insight into the current state of chronic kidney disease in pedia...

Lisa M. Satlin, Sharon P. Andreoli, H. William Schnaper in Pediatric Nephrology (2009)

Article

Cell signal transduction through the mitogen-activated protein kinase pathway

H. William Schnaper in Pediatric Nephrology (1998)

Article

Integrin receptors, the cytoskeleton, and glomerular cell function

H. William Schnaper in Pediatric Nephrology (1996)

Article

Balance between matrix synthesis and degradation: a determinant of glomerulosclerosis

In glomerular health and disease, the balance between extracellular matrix (ECM) protein synthesis and degradation determines the amount of matrix that accumulates locally. While cell and whole animal regulati...

H. William Schnaper in Pediatric Nephrology (1995)

Article

Apoptosis: death as a “vital” biological function

H. William Schnaper in Pediatric Nephrology (1994)

Article

Immunization practices in childhood nephrotic syndrome: a survey of North American pediatric nephrologists

The indications for immunizing children with minimal change nephrotic syndrome are a subject of some controversy, since it has been reported that immunization may not be effective or may serve as an immunogeni...

H. William Schnaper in Pediatric Nephrology (1994)

Article

Call for a registry of complications of immunization in nephrotic children!

H. William Schnaper in Pediatric Nephrology (1994)

Article

The endothelium as an immune organ: studies of endothelial-leukocyte interactions

H. William Schnaper in Pediatric Nephrology (1993)

Article

Regulation of cell function by extracellular matrix

The extracellular matrix (ECM) provides structural support and adhesive substrates for the body tissues. Recent advances in our understanding of the biology of matrix indicate that the ECM also plays a signifi...

H. William Schnaper, Hynda K. Kleinman in Pediatric Nephrology (1993)

Article

Hormonal mediators of immune function: new targets for therapeutic intervention

H. William Schnaper in Pediatric Nephrology (1992)

Article

Steroid-dependent nephrotic syndrome following renal transplantation for congenital nephrotic syndrome

A boy developed recurrent steroid-responsive nephrotic syndrome following renal transplantation for congenital nephrotic syndrome. The first episode was associated with mild tubulointerstitial rejection on kid...

Pascale H. Lane, H. William Schnaper, Robert L. Vernier… in Pediatric Nephrology (1991)

Article

Immunological mediators and glomerular cell function

H. William Schnaper in Pediatric Nephrology (1991)

Article

A regulatory system for soluble immune response suppressor production in steroid-responsive nephrotic syndrome

H. William Schnaper in Pediatric Nephrology (1991)