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11 Result(s)

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  1. Article

    Open Access

    PIAS1 is a determinant of poor survival and acts as a positive feedback regulator of AR signaling through enhanced AR stabilization in prostate cancer

    Novel drugs like Abiraterone or Enzalutamide, which target androgen receptor (AR) signaling to improve androgen deprivation therapy (ADT), have been developed during the past years. However, the application of...

    M Puhr, J Hoefer, A Eigentler, D Dietrich, G van Leenders, B Uhl, M Hoogland… in Oncogene (2016)

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  2. No Access

    Article

    Long-term biochemical evaluation of the androgen receptor pathway in males with disorders of sex development

    Disorders of sex (DSD) development represent a serious condition. Most of the underlying mechanisms remain unclear. Disturbances within the androgen receptor (AR) pathway frequently account for 46 XY-DSDs. The...

    C. Schwentner, J. Czyz, J. Seibold, T. Todenhoefer… in World Journal of Urology (2011)

  3. No Access

    Article

    Mechanismen der Kontrolle des Tonus der glatten Muskulatur der Prostata und ihre potentielle Bedeutung für die Pharmakotherapie des benignen Prostatasyndroms

    S. Ückert, G. Kedia, H. Klocker, M. Sormes, G. Bartsch, Prof. Dr. U. Jonas in Der Urologe (2007)

  4. No Access

    Article

    Dihydrotestosteron und die Rolle der 5α-Reduktasehemmer bei der benignen Prostatahyperplasie

    Die Entstehung der benignen Prostatahyperplasie (BPH) beruht auf 2 Faktoren: den testikulären Androgenen und dem Alterungsprozess. Das wichtigste Androgen in der Prostata ist das Dihydrotestosteron (DHT). Beim...

    G. Bartsch, R. S. Rittmaster, H. Klocker in Der Urologe A (2002)

  5. No Access

    Article

    Dihydrotestosterone and the concept of 5α-reductase inhibition in human benign prostatic hyperplasia

    The development of human benign prostatic hyperplasia (BPH) clearly requires a combination of testicular androgens and the ageing process. Although the role of androgens as the causative factor for human beni...

    G. Bartsch, R. Rittmaster, H. Klocker in World Journal of Urology (2002)

  6. No Access

    Article

    Androgen receptor – an update of mechanisms of action in prostate cancer

    Androgen receptor (AR), a key nuclear transcription factor in the prostate gland, is expressed in all histological types and stages of prostate cancer. The AR regulates proliferation of prostate cancer cells ...

    Z. Culig, A. Hobisch, G. Bartsch, H. Klocker in Urological Research (2000)

  7. No Access

    Article

    Activation of the androgen receptor by polypeptide growth factors and cellular regulators

    The polypeptide growth factors insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), and transforming growth factor-α (TGF-α); second-messenger cyclic adenosine monophosphate (cAMP); protein kin...

    Z. Culig, A. Hobisch, M. V. Cronauer, A. Hittmair, C. Radmayr… in World Journal of Urology (1995)

  8. No Access

    Chapter and Conference Paper

    PSA als First-line-Screeningtest für das Prostatakarzinom — Ergebnisse aus Tirol (Österreich)

    Das Glykoprotein PSA, exklusiv von Prostataepithelzellen produziert, hat eine Reihe von Applikationen im Management bei Männern mit Prostatakarzinom. Es ist heute durchaus bekannt, daß erhöhtes prostataspezifi...

    A. Reissigl, H. Strasser, W. Horninger, R. Peschel… in Screening des Prostatakarzinoms (1995)

  9. No Access

    Article

    Androgen signal transduction and prostatic carcinoma

    In the prostate, androgen action affects the growth of the gland, its morphology, and regulation of protein expression. Endocrine therapy of non-organ-confined tumors is based on the androgen dependence of the...

    H. Klocker, Z. Culig, F. Kaspar, A. Hobisch, J. Eberle… in World Journal of Urology (1994)

  10. No Access

    Article

    Growth-stimulating effect of adrenal androgens on the R3327 Dunning prostatic carcinoma

    Adrenal androgens are discussed as a reason for tumor progression after androgen ablation therapy. Because of the difference in the secretion of androgens by the adrenals of humans and rats, there is no reliab...

    C.-D. Schiller, M. R. Schneider, H. Hartmann, A.-H. Graf, H. Klocker… in Urological Research (1991)

  11. No Access

    Chapter and Conference Paper

    Aging and DNA Repair

    Aging is a central problem for eukaryotic organisms. However, not only are the molecular mechanisms underlying this general phenomenon unknown but even the basic features of aging at the cellular level have no...

    M. Hirsch-Kauffmann, H. Schwaiger, B. Auer, R. Schneider… in Molecular Mechanisms of Aging (1990)