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Article
Open AccessCariprazine, A Broad-Spectrum Antipsychotic for the Treatment of Schizophrenia: Pharmacology, Efficacy, and Safety
Schizophrenia is characterized by positive, negative, cognitive, and affective symptoms. Antipsychotic medications, which work by blocking the dopamine D2 receptor, are the foundation of pharmacotherapy for schiz...
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Article
Open AccessLinking PANSS negative symptom scores with the Clinical Global Impressions Scale: understanding negative symptom scores in schizophrenia
Understanding how rating scale improvement corresponds to a clinical impression in patients with negative symptoms of schizophrenia may help define the clinical relevance of change in this patient population. ...
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Article
Open AccessThe safety and tolerability of cariprazine in long-term treatment of schizophrenia: a post hoc pooled analysis
Schizophrenia is a chronic and debilitating neuropsychiatric disorder that often requires long-term pharmacotherapy to manage symptoms and prevent relapse. Cariprazine is a potent dopamine D3 and D2 receptor part...
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Article
Antiangiogenic Effects of Radiotherapy but not Initial Microvessel Density Predict Survival in Inoperable Oropharyngeal Squamous Cell Carcinoma
To evaluate the predictive value of intratumoral microvessel density (MVD) in patients with locally advanced, primarily inoperable oropharyngeal cancer (OPCC) treated with irradiation alone.
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Article
Interstitial High-Dose-Rate Brachytherapy in the Treatment of Base of Tongue Carcinoma
To date none of the studies examined the feasibility and efficacy of interstitial high-dose-rate (HDR) brachytherapy in the treatment of carcinoma of the tongue base. Therefore the aim of this study was to con...
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Article
Iodine-125 Brachytherapy of Brain Stem Tumors
To report on iodine-125 (125I) interstitial irradiation in the treatment of brain stem tumors.
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Article
Effects of Radiation Treatment Planning and Patient Fixation on the Results of Postoperative Radiotherapy of Childhood Medulloblastoma
To assess the prognostic factors and the benefit of introducing head fixation and CT-assisted radiation treatment planning following postoperative radiotherapy in 83 children with medulloblastoma.
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Article
Low-Dose Irradiation and Short-Exposure Suboptimal-Dose Paclitaxel Adversely Modulate Metastatic Potential of Squamous Carcinoma Cells
Low-dose irradiation and suboptimal drug concentrations may induce unexpected biological responses. Paclitaxel (PTX) is a widely used drug, which has a range of antitumoral effects and which is also regarded a...
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Article
Locoregional Failure 15 Years after Mastectomy in Women with One to Three Positive Axillary Nodes with or without Irradiation
There is insufficient evidence to suggest the routine use of postmastectomy radiotherapy (PMRT) in patients with one to three positive axillary nodes and T1/2 tumors. We have assessed the risk of locoregional...
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Article
Electron and High-Dose-Rate Brachytherapy Boost in the Conservative Treatment of Stage I–II Breast Cancer
To evaluate the effect of electron and high-dose-rate brachytherapy (HDR BT) boost on local tumor control (LTC), side effects and cosmesis after breast-conserving surgery (BCS) in a prospective randomized study.
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Article
Radiotherapy Confined to the Tumor Bed Following Breast Conserving Surgery
The standard technique of radiotherapy (RT) after breast conserving surgery (BCS) is to treat the entire breast up to a total dose of 45–50 Gy with or without tumor bed boost. The majority of local recurrence...
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Article
The role of boost irradiation in the conservative treatment of stage I-II breast cancer
In this article, we review the current status, indication, technical aspects, controversies, and future prospects of boost irradiation after breast conserving surgery (BCS). BCS and radiotherapy (RT) of the co...
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Article
Possibilities of preventing osteoradionecrosis during complex therapy of Tumors of the oral cavity
In recent years, there has been a dramatic increase in the number of tumors of the head and neck. Their successful treatment is one of the greatest challenges for physicians dealing with oncotherapy. An organi...
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Article
CT-Image Based Conformal Brachytherapy of Breast Cancer The Significance of Semi-3-D and 3-D Treatment Planning
To compare the conventional 2-D, the simulator-guided semi-3-D and the recently developed CT-guided 3-D brachytherapy treatment planning in the interstitial radiotherapy of breast cancer.
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Article
Polymorphous Low-Grade Adenocarcinoma of the Nasopharynx Case Report and Review of the Literature
The polymorphous low-grade adenocarcinoma of the nasopharynx is a rare disease. Polymorphous low-grade adenocarcinoma is a minor salivary gland neoplasm which occurs frequently in the mucosa of the soft and h...
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Article
Total Body Irradiation before Bone Marrow Transplantation Technique and Acute Toxicity
To evaluate the total body irradiation methods in the National Institute of Oncology between January 1984 and February 1998.
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Article
Predictive value of p53, Bcl2 and bax in the radiotherapy of head and neck cancer
Radiation is known to induce DNA damage resulting in the onset of apoptosis. The apoptosis is modulated by p53, Bcl2 and Bax proteins. High level of wild type p53 is required for radiation induced apoptosis. T...
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Article
Strahlentherapie und Onkologie—Publikationsorgan der deutschsprachigen Radioonkologen
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Article
The first 4 years of the Hungarian Society for Radiation Oncology
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Article
The vulnerability of gerbils to focal Cerebral Ischemia
Gerbils of both sexes were used to study the effects of 30-min ischemia and subsequent recirculation for 4 and 8 days. The mortality rate was 9% during ischemia and 34% in the recirculation period. No close co...
