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Article
Open AccessAn oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy
Tumor-specific T cells are crucial in anti-tumor immunity and act as targets for cancer immunotherapies. However, these cells are numerically scarce and functionally exhausted in the tumor microenvironment (TM...
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Article
Open AccessThe effects of restraint stress on ceramide metabolism disorders in the rat liver: the role of CerS6 in hepatocyte injury
Stress is implicated in various pathological conditions leading to liver injury. Existing evidence suggests that excessive stress can induce mitochondrial damage in hepatocytes, yet the underlying mechanism re...
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Article
Open AccessAn RBD bispecific antibody effectively neutralizes a SARS-CoV-2 Omicron variant
Potent neutralizing antibodies (nAbs) against SARS-CoV-2 are a promising therapeutic against the ongoing COVID-19 pandemic. However, the continuous emergence of neutralizing antibody escape variants makes it c...
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Article
Open AccessDesign and experiment of a combined peeling machine for water chestnut
Water chestnut is a characteristic aquatic vegetable in China, and its demand for peeling fresh fruit is increasing rapidly. Aiming at the existing problems of high labor intensity and low efficiency of manual...
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Article
Open AccessMutagenesis of the di-leucine motif in the cytoplasmic tail of newcastle disease virus fusion protein modulates the viral fusion ability and pathogenesis
Newcastle disease virus (NDV) is a highly infectious viral disease, which can affect chickens and many other kinds of birds. The main virulence factor of NDV, the fusion (F) protein, is located on the viral en...
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Article
Open AccessDesign and test of smashing and scattering device of double-channel feeding ratoon rice harvester
Since it is requested that the smashed straw should not be scattered onto the stubble in the first season harvest, a smashing and scattering device matched with the first season harvester of ratoon rice was de...
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Article
A fatal case of accidental oral formaldehyde poisoning and its pathomorphological characteristics
Formaldehyde is a colourless irritating gas at room temperature, which, therefore, is usually stored in liquid form. This compound is often used as an antiseptic, disinfectant and fumigant in biology and medic...
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Article
A study on the infection status and transmission of avian leukosis virus subgroup J in Hy-line brown roosters
Avian leukosis virus subgroup J (ALV-J) is the most prevalent subgroup in chickens and exhibits increased pathogenicity and stronger horizontal and vertical transmission ability among different breeds. Althoug...
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Article
Open AccessLongitudinal axial flow rice thresher feeding rate monitoring based on force sensing resistors
The threshing unit is the main working unit of the combine harvester and plays an essential role in rice threshing efficiency, seed loss, and damage. Every thresher has its limitation for feeding, and when the...
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Article
Open AccessThe dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity
The adaptive immunity that protects patients from coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is not well characterized. In particular, the asym...
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Article
Effects of annealing temperature and heating rate on microstructure, magnetic, and mechanical properties of high-Bs Fe81.7−xSi4B13NbxCu1.3 nanocrystalline alloys
The effects of annealing temperature and heating rate on the microstructure, magnetic, and mechanical properties of melt-spun Fe81.7−xSi4B13Cu1.3Nbx (x = 0–4) alloy ribbons have been investigated. With increasing...
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Article
Open AccessDisease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19
COVID-19 patients exhibit differential disease severity after SARS-CoV-2 infection. It is currently unknown as to the correlation between the magnitude of neutralizing antibody (NAb) responses and the disease ...
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Article
Open AccessPathogenic characteristics of a QX-like infectious bronchitis virus strain SD in chickens exposed at different ages and protective efficacy of combining live homologous and heterologous vaccination
Continued reports of infections with infectious bronchitis virus (IBV) variants have occurred since its first isolation in the 1930s. Currently, QX-like IBVs are the predominant circulating genotype around the...
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Article
Microstructure and Properties of AlCoCrFeNiSi High-Entropy Alloy Coating on AISI 304 Stainless Steel by Laser Cladding
In this paper, to improve the hardness and wear resistance, AlCoCrFeNiSi HEA coatings were synthesized on AISI 304 stainless steel by laser cladding. The microstructure, chemical composition, constituent phase...
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Article
NP protein and F protein of pigeon paramyxovirus type 1 are associated with its low pathogenicity in chickens
In this study, we investigated which structural proteins of pigeon paramyxovirus type 1 (PPMV-1) are responsible for its low pathogenicity in chickens. The results revealed that the pathogenicity of the virus ...
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Article
Open AccessThe glutamic residue at position 402 in the C-terminus of Newcastle disease virus nucleoprotein is critical for the virus
The nucleocapsid proteins (NPs) of Newcastle disease virus (NDV) and other paramyxoviruses play an important functional role during genomic RNA replication. Our previous study showed that the NP-encoding gene ...
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Article
Open AccessEfficacy of an inactivated bivalent vaccine against the prevalent strains of Newcastle disease and H9N2 avian influenza
Newcastle disease (ND) and avian influenza subtype H9N2 (H9N2 AI) are two of the most important diseases of poultry, causing severe economic losses in the global poultry industry. Vaccination is an effective w...
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Article
Open AccessContribution of HN protein length diversity to Newcastle disease virus virulence, replication and biological activities
To evaluate the contribution of length diversity in the hemagglutinin-neuraminidase (HN) protein to the pathogenicity, replication and biological characteristics of Newcastle disease virus (NDV), we used rever...
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Article
Open AccessGeneration of biallelic knock-out sheep via gene-editing and somatic cell nuclear transfer
Transgenic sheep can be used to achieve genetic improvements in breeds and as an important large-animal model for biomedical research. In this study, we generated a TALEN plasmid specific for ovine MSTN and trans...
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Article
Expression patterns of Nurr1 in rat retina development
Nurr1 is a member of the nuclear receptor superfamily, and is involved in regulating the differentiation, migration and maturation of mesencephalic dopaminergic neurons. The present study was designed to obser...
