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Article
Open AccessThe Garden of Forking Paths: Reinterpreting Haseman-Elston Regression for a Genotype-by-Environment Model
Haseman-Elston regression (HE-reg) has been known as a classic tool for detecting an additive genetic variance component. However, in this study we find that HE-reg can capture GxE under certain conditions, so...
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Article
Open AccessLithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study...
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Article
Open AccessAssociations of the circulating levels of cytokines with risk of amyotrophic lateral sclerosis: a Mendelian randomization study
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that is accompanied by muscle weakness and muscle atrophy, typically resulting in death within 3–5 years from the disease occurrence. Though ...
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Article
Open AccessBoth indirect maternal and direct fetal genetic effects reflect the observational relationship between higher birth weight and lower adult bone mass
Birth weight is considered not only to undermine future growth, but also to induce lifelong diseases; the aim of this study is to explore the relationship between birth weight and adult bone mass.
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Article
Open AccessThe value of lymphocyte-to-monocyte ratio and neutrophil-to-lymphocyte ratio in differentiating pneumonia from upper respiratory tract infection (URTI) in children: a cross-sectional study
Early and accurate diagnosis of pediatric pneumonia in primary health care can reduce the chance of long-term respiratory diseases, related hospitalizations and mortality while lowering medical costs. The aim ...
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Article
Open AccessObservational and genetic evidence highlight the association of human sleep behaviors with the incidence of fracture
We combined conventional evidence from longitudinal data in UK Biobank and genetic evidence from Mendelian randomization (MR) approach to infer the causality between sleep behaviors and fracture risk. We found...
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Article
Open AccessA rapid screening model for early predicting novel coronavirus pneumonia in Zhejiang Province of China: a multicenter study
Novel coronavirus pneumonia (NCP) has been widely spread in China and several other countries. Early finding of this pneumonia from huge numbers of suspects gives clinicians a big challenge. The aim of the stu...
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Article
Correction to: A rapid genomic selection method combining Haseman-Elston (HE) model and algorithm for proven and young (APY)
In the original version of this article the co-corresponding author name is missing.
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Article
A rapid genomic selection method combining Haseman-Elston (HE) model and algorithm for proven and young (APY)
To increase the predictive accuracy of genomic selection, large-scale phenotypic and genomic data is needed, which results in enormous consumption of computational resources, hampering the feasibility of genom...
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Article
Sun et al.’s study led to the underperformance of EigenGWAS
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Article
A new genomic prediction method with additive-dominance effects in the least-squares framework
In our previous work, we proposed a genomic prediction method combing identical-by-state-based Haseman-Elston regression and best linear prediction with additive variance component only (HEBLP|A herein), the m...
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Article
Open AccessPerformance of risk prediction for inflammatory bowel disease based on genoty** platform and genomic risk score method
Predicting risk of disease from genotypes is being increasingly proposed for a variety of diagnostic and prognostic purposes. Genome-wide association studies (GWAS) have identified a large number of genome-wid...
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Article
A fast genomic selection approach for large genomic data
We propose a novel computational method for genomic selection that combines identical-by-state (IBS)-based Haseman–Elston (HE) regression and best linear prediction (BLP), called HE-BL...
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Article
Genome-wide association study identifies 74 loci associated with educational attainment
A genome-wide association study in 293,723 individuals identifies 74 genetic variants associated with educational attainment, which, although only explaining a small proportion of the variation in educational ...
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Article
A unified GMDR method for detecting gene–gene interactions in family and unrelated samples with application to nicotine dependence
Gene–gene and gene–environment interactions govern a substantial portion of the variation in complex traits and diseases. In convention, a set of either unrelated or family samples are used in detection of suc...
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Article
Development of universal genetic markers based on single-copy orthologous (COSII) genes in Poaceae
We develop a set of universal genetic markers based on single-copy orthologous (COSII) genes in Poaceae.
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Article
Association of amyloid precursor protein-binding protein, family B, member 1 with nicotine dependence in African and European American smokers
Although epidemiological studies reveal that cigarette smoking is inversely associated with Alzheimer’s disease (AD) and Parkinson’s disease (PD), the underlying mechanism remains largely unknown. Considering ...
