488 Result(s)

Article

Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing

Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pul...

Shuang-** Ren, Gang Fu, **u-Gao Jiang, Rong Zeng, You-Gang Miao, Hai Xu… in Nature (2003)

Article

Genetic polymorphisms of CYP2A13 and its relationship to nasopharyngeal carcinoma in the Cantonese population

Nasopharyngeal carcinoma (NPC) is characterized by a high prevalence in Southern China, especially among Cantonese individuals of the Guangdong Province. Epidemiological studies have suggested that frequent ex...

Ju-Hong Jiang, Wei-Hua Jia, Han-Kui Chen… in Journal of Translational Medicine (2004)

Article

Construction of phospholamban antisense RNA recombinant adeno-associated virus vector and its effects in rat cardiomyocytes

To construct a recombinant adeno-associated virus (rAAV) vector containing gene encoding phospholamban antisense RNA (asPLB), and analyse its effect on expression of PLB, expression and activity of sarco-endop...

Jiang Li, Shen-jiang Hu, Jian Sun, Zhao-hui Zhu, **a Zheng… in Acta Pharmacologica Sinica (2005)

Article

Swietenia mahagony extract shows agonistic activity to PPAR γ and gives ameliorative effects on diabetic db/db mice

To search the peroxisome proliferator-activated receptor γ (PPARγ) agonists from Swietenia mahagony extract (SmE) and observe the possible ameliorative effects of SmE on diabetic db/db mice.

Dan-dan Li, Jun-hua Chen, Qing Chen, Guo-wei Li, **g Chen… in Acta Pharmacologica Sinica (2005)

Article

Novel cyclophilin D inhibitors derived from quinoxaline exhibit highly inhibitory activity against rat mitochondrial swelling and Ca²⁺ uptake/release

To investigate methods for identifying specific cyclophilin D (CypD) inhibitors derived from quinoxaline, thus develo** possible lead compounds to inhibit mitochondrial permeability transition (MPT) pore ope...

Hong-xia Guo, Feng Wang, Kun-qian Yu, **g Chen, Dong-lu Bai… in Acta Pharmacologica Sinica (2005)

Article

Thrombocytopenia in the experimental leptospirosis of guinea pig is not related to disseminated intravascular coagulation

Thrombocytopenia is commonly observed in severe leptospirosis. However, previous studies on coagulation alterations during leptospirosis resulted in inconsistent conclusions. Some findings showed that the prom...

Hong-Liang Yang, Xu-Cheng Jiang, **ang-Yan Zhang, Wen-Jun LI… in BMC Infectious Diseases (2006)

Article

Life time suicidal thoughts in an urban community in Hanoi, Vietnam

Suicidal thought is a risk factor and a stage in the suicidal process from planning to attempting and dying by suicide. To date, studies on suicidal thought in the general population, especially in Asian commu...

Huong Tran Thi Thanh, Trung Nam Tran, Guo-**n Jiang, Antoon Leenaars… in BMC Public Health (2006)

Article

Assembly, Morphology and Thermal Stability of Polyamide 6 Nanotubes

Polyamide 6 (PA6) nanotubes array has been prepared successfully using small pore anodic aluminum oxide (AAO) membrane (200 nm) as the template via polymer solution and melt wetting method. The investigation of S...

Jian-Jiang Li, Guo-Jun Song, **-Lin She, ** Han, Zhi Peng, Dong Chen in Polymer Journal (2006)

Article

In silico and microarray-based genomic approaches to identifying potential vaccine candidates against Leptospira interrogans

Currently available vaccines against leptospirosis are of low efficacy, have an unacceptable side-effect profile, do not induce long-term protection, and provide no cross-protection against the different serov...

Hong-Liang Yang, Yong-Zhang Zhu, **-Hong Qin, ** He, Xu-Cheng Jiang… in BMC Genomics (2006)

Article

Recent advances in basic neurosciences and brain disease: from synapses to behavior

Understanding basic neuronal mechanisms hold the hope for future treatment of brain disease. The 1st international conference on synapse, memory, drug addiction and pain was held in beautiful downtown Toronto,...

Guo-Qiang Bi, Vadim Bolshakov, Guojun Bu, Catherine M Cahill… in Molecular Pain (2006)

Article

Nitrofen suppresses cell proliferation and promotes mitochondria-mediated apoptosis in type II pneumocytes

To characterize the molecular mechanisms of nitrofen-induced pulmonary hypoplasia.

Qiang-song Tong, Li-duan Zheng, Shao-tao Tang, Guo-song Jiang… in Acta Pharmacologica Sinica (2007)

Article

Reduced Anxiety and Depression-Like Behaviors in Mice Lacking GABA Transporter Subtype 1

γ-Aminobutyric acid (GABA) transporter subtype 1 (GAT1), which transports extracellular GABA into presynaptic neurons, plays an important regulatory role in the function of GABAergic systems. However, the contr.....

Guo-**ang Liu, Guo-Qiang Cai, You-Qing Cai, Zhe-** Sheng… in Neuropsychopharmacology (2007)

Article

Genetic diversity among major endemic strains of Leptospira interrogans in China

Leptospirosis is a world-widely distributed zoonosis. Humans become infected via exposure to pathogenic Leptospira spp. from contaminated water or soil. The availability of genomic sequences of Leptospira interro...

** He, Yue-Ying Sheng, Yao-Zhou Shi, **u-Gao Jiang, **-Hong Qin… in BMC Genomics (2007)

Article

Efficient growth inhibition of ErbB2-overexpressing tumor cells by anti-ErbB2 ScFv-Fc-IL-2 fusion protein in vitro and in vivo

To investigate the antitumor activities of an anti-ErbB2 scFv-Fc-interleukin 2 (IL-2) fusion protein (HFI) in vitro and in vivo.

Ming Shi, Ling Zhang, Hong-tao Gu, Feng-qin Jiang, Lu Qian… in Acta Pharmacologica Sinica (2007)

Article

Protective effect of raloxifene on lipopolysaccharide and acid- induced acute lung injury in rats

To evaluate the protective effect of oral raloxifene on acute lung injury.

Guang-ju Zhou, Hong Zhang, Sheng-de Zhi, Guo-** Jiang… in Acta Pharmacologica Sinica (2007)

Article

Alterations of GPI transamidase subunits in head and neck squamous carcinoma

GPI anchor attachment is catalyzed by the GPI transamidase (GPIT) complex. GAA1, PIG-T and PIG-U are the three of five GPIT subunits. Previous studies demonstrated amplification and overexpression of GPIT subunit...

Wei-Wen Jiang, Marianna Zahurak, Zeng-Tong Zhou, Hannah Lui Park… in Molecular Cancer (2007)

Article

Electrophysiological characterization of a novel Kv channel blocker N, N′-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(4-methyl)-benzenesulfonamide found in virtual screening

N,N′-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(4-methyl)-benzenesulfonamide (OMBSA) is a hit compound with potent voltage-gated K⁺ (Kv) channel-blocking activities that was found while searching the MDL Avail...

Zhao-bing Gao, Xue-qin Chen, Hua-liang Jiang, Hong Liu… in Acta Pharmacologica Sinica (2008)

Article

Natural jasmonates of different structures suppress the growth of human neuroblastoma cell line SH-SY5Y and its mechanisms

Recent evidence has indicated that members of natural jasmonates, a family of plant stress hormones, exhibit anticancer activity. The current study was undertaken to investigate the effects of jasmonates on the i...

Qiang-song Tong, Guo-song Jiang, Li-duan Zheng, Shao-tao Tang… in Acta Pharmacologica Sinica (2008)

Article

Medication of l-tetrahydropalmatine significantly ameliorates opiate craving and increases the abstinence rate in heroin users: a pilot study

Drug addiction is a chronic brain disease with constant relapse requiring long-term treatment. New pharmacological strategies focus on the development of an effective antirelapse drug. This study examines the ...

Zheng Yang, Yong-cong Shao, Shi-jiang Li, Jian-lin Qi… in Acta Pharmacologica Sinica (2008)

Article

Transplantation of marrow stromal cells to rescue retinal cells in SI-induced retinal degeneration in rats

Yuan Guan, Lu Cui, Yuanyuan Gong, Caihong **a, Naihe **g, Yalan Wu… in Cell Research (2008)