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Article
Open AccessEstablishment of a leptospirosis model in guinea pigs using an epicutaneous inoculations route
Leptospires are presumed to enter their host via small abrasions or breaches of the skin. The intraperitoneal route, although commonly used in guinea pig and hamster models of leptospirosis, does not reflect c...
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Article
Open AccessIn silico and microarray-based genomic approaches to identifying potential vaccine candidates against Leptospira interrogans
Currently available vaccines against leptospirosis are of low efficacy, have an unacceptable side-effect profile, do not induce long-term protection, and provide no cross-protection against the different serov...
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Article
Open AccessThrombocytopenia in the experimental leptospirosis of guinea pig is not related to disseminated intravascular coagulation
Thrombocytopenia is commonly observed in severe leptospirosis. However, previous studies on coagulation alterations during leptospirosis resulted in inconsistent conclusions. Some findings showed that the prom...
