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Article
Discovery of N-(3,5-bis(1-pyrrolidylmethyl)-4-hydroxybenzyl)-4-methoxybenzenesulfamide (sulcardine) as a novel anti-arrhythmic agent
To investigate the anti-arrhythmic effects of sulfamide analogues of changrolin and to characterize the sulfate of compound 6f (sulcardine sulfate, Sul) as a novel anti-arrhythmic agent.
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Article
Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors
To design novel bifunctional derivatives of huperzine B (HupB) based on the concept of dual binding site of acetylcholinesterase (AChE) and evaluate their pharmacological activities for seeking new drug candid...
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Article
Pharmacodynamic Study of FS-0311: A Novel Highly Potent, Selective Acetylcholinesterase Inhibitor
(1) This study was to evaluate the anti-cholinesterase (ChE), cognition enhancing and neuroprotective effects of FS-0311, a bis-huperzine B derivative. (2) ChE activity was evaluated using a spectrophotometric...
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Article
Novel cyclophilin D inhibitors derived from quinoxaline exhibit highly inhibitory activity against rat mitochondrial swelling and Ca2+ uptake/release
To investigate methods for identifying specific cyclophilin D (CypD) inhibitors derived from quinoxaline, thus develo** possible lead compounds to inhibit mitochondrial permeability transition (MPT) pore ope...
