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Article
Cells play tug-of-war to start moving collectively
Orderly or coherent multicellular flows are fundamental in biology, but their triggers are not understood. In epithelial tissues, the tug-of-war between cells is now shown to lead to intrinsic asymmetric distr...
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Article
Open AccessDeeP4med: deep learning for P4 medicine to predict normal and cancer transcriptome in multiple human tissues
P4 medicine (predict, prevent, personalize, and participate) is a new approach to diagnosing and predicting diseases on a patient-by-patient basis. For the prevention and treatment of diseases, prediction play...
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Article
Tunable nano-engineered anisotropic surface for enhanced mechanotransduction and soft-tissue integration
Electrochemically engineered titania (TiO2) nanopores enable tailored cellular function; however, the cellular mechanosensing mechanisms dictating the cell response and soft tissue integration are yet to be eluci...
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Article
Open AccessRegulating life after death: how mechanical communication mediates the epithelial response to apoptosis
It is increasingly evident that cells in tissues and organs can communicate with one another using mechanical forces. Such mechanical signalling can serve as a basis for the assembly of cellular communities. F...
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Article
Open AccessA deep convolutional neural network for segmentation of whole-slide pathology images identifies novel tumour cell-perivascular niche interactions that are associated with poor survival in glioblastoma
Glioblastoma is the most aggressive type of brain cancer with high-levels of intra- and inter-tumour heterogeneity that contribute to its rapid growth and invasion within the brain. However, a spatial characte...
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Article
Open Access3D-printed microplate inserts for long term high-resolution imaging of live brain organoids
Organoids are a reliable model used in the study of human brain development and under pathological conditions. However, current methods for brain organoid culture generate tissues that range from 0.5 to 2 mm o...
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Article
Open AccessDeepSurvNet: deep survival convolutional network for brain cancer survival rate classification based on histopathological images
Histopathological whole slide images of haematoxylin and eosin (H&E)-stained biopsies contain valuable information with relation to cancer disease and its clinical outcomes. Still, there are no highly accurate...
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Article
Open AccessMeeting Report: The 8th Barossa Meeting—Cell Signaling in Cancer Medicine in the Barossa Valley, Australia
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Article
Open AccessMechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling
Mechanotransduction is a strong driver of mesenchymal stem cell (MSC) fate. In vitro, variations in matrix mechanics invoke changes in MSC proliferation, migration and differentiation. However, when incorporat...
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Article
Open AccessAuthor Correction: Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1
A correction to this article has been published and is linked from the HTML version of this article.
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Article
Open AccessLive imaging molecular changes in junctional tension upon VE-cadherin in zebrafish
Forces play diverse roles in vascular development, homeostasis and disease. VE-cadherin at endothelial cell-cell junctions links the contractile acto-myosin cytoskeletons of adjacent cells, serving as a tensio...
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Article
Open AccessTyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1
Contractile adherens junctions support cell−cell adhesion, epithelial integrity, and morphogenesis. Much effort has been devoted to understanding how contractility is established; however, less is known about ...
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Article
Open AccessLaser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis
Remarkably little is known about how intracellular pathogens exit the host cell in order to infect new hosts. Pathogenic chlamydiae egress by first rupturing their replicative niche (the inclusion) before rapi...
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Article
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions
Actomyosin at the epithelial zonula adherens (ZA) generates junctional tension for tissue integrity and morphogenesis. This requires the RhoA GTPase, which establishes a strikingly stable active zone at the ZA...
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Article
Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking
In neurosecretory cells, secretory vesicles (SVs) undergo Ca2+-dependent fusion with the plasma membrane to release neurotransmitters. How SVs cross the dense mesh of the cortical actin network to reach the plasm...
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Article
Cortical F-actin stabilization generates apical–lateral patterns of junctional contractility that integrate cells into epithelia
E-cadherin cell–cell junctions couple the contractile cortices of epithelial cells together, generating tension within junctions that influences tissue organization. Although junctional tension is commonly stu...
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Article
Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens
The biological impact of Rho depends critically on the precise subcellular localization of its active, GTP-loaded form. This can potentially be determined by the balance between molecules that promote nucleoti...
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Article
Spatial Organization and Stoichiometry of N-Terminal Domain-Mediated Glycosyltransferase Complexes in Golgi Membranes Determined by Fret Microscopy
The functional link between glycolipid glycosyltransferases (GT) relies on the ability of these proteins to form organized molecular complexes. The organization, stoichiometry and composition of these complexe...
