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  1. Article

    Open Access

    Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson’s models via regulating autophagy-lysosome pathway

    The abnormal accumulation of α-synuclein (α-syn) is a crucial factor for the onset and pathogenesis of Parkinson’s disease (PD), and the autophagy-lysosome pathway (ALP) contributes to α-syn turnover. AMP-acti...

    Jie Xu, Yun-Lin Ao, Chunhui Huang, **ubao Song, Guiliang Zhang… in npj Parkinson's Disease (2022)

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    Article

    The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer’s Disease

    T-006, a small-molecule compound derived from tetramethylpyrazine (TMP), has potential for the treatment of neurological diseases. In order to investigate the effect of T-006 prophylactic treatment on an Alzhe...

    Guiliang Zhang, Jiahui Wu, Chunhui Huang… in Journal of Molecular Neuroscience (2021)