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    Article

    Promethazine both facilitates and inhibits nociception in rats: Effect of the testing procedure

    The present study demonstrates that low doses of promethazine (1.25–5 mg/kg SC) dose-dependently facilitate nociception in the vocalization test in rats. However, this effect disappeared gradually with increas...

    Gudrun H. M. Paalzow, Lennart K. Paalzow in Psychopharmacology (1985)

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    Chapter

    Kinetics of Drug Action

    We all probably agree that the rapid progress in pharmacokinetics observed over the past decade has not been matched by a rapid development in our knowledge of the kinetics of drug action. The main reasons for...

    Lennart K. Paalzow, Gudrun H. M. Paalzow, Peer Tfelt-Hansen in Pharmacokinetics (1984)

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    Article

    Yohimbine both increases and decreases nociceptive thresholds in rats: Evaluation of the dose-response relationship

    The effect of yohimbine on a response to nociceptive stimulation mediated by supraspinal structures was studied after subcutaneous administration in doses from 0.25 mg/kg up to 25 mg/kg. The results showed tha...

    Gudrun H. M. Paalzow, Lennart K. Paalzow in Naunyn-Schmiedeberg's Archives of Pharmacology (1983)