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Article
Open AccessThe putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells
Triptans are anti-migraine drugs with a potential central site of action. However, it is not known to what extent triptans cross the blood–brain barrier (BBB). The aim of this study was therefore to determine ...
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Article
Open AccessMulti-omic analyses of triptan-treated migraine attacks gives insight into molecular mechanisms
Migraine is a common, polygenic disorder that is characterized by moderate to severe headache attacks. Migraine attacks are commonly treated with triptans, i.e. serotonin receptor agonists. However, triptans a...
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Article
Zavegepant for the acute treatment of migraine: look before lea**
The armamentarium of acute medications for migraine is set to expand further with the results of a phase III trial, in which intranasal administration of zavegepant was superior to placebo in treating a single...
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Article
Open AccessPrevention of migraine with monoclonal antibodies against CGRP or the CGRP receptor
Monoclonal antibodies against the calcitonin gene-related peptide (CGRP) receptor (Erenumab) or against CGRP (Eptinezumab, Fremanezumab, Galcanezumab) are new substances for the preventive treatment of migrain...
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Article
Pharmacokinetic Variability of Drugs Used for Prophylactic Treatment of Migraine
In this review, we evaluate the variability in the pharmacokinetics of 11 drugs with established prophylactic effects in migraine to facilitate ‘personalized medicine’ with these drugs. PubMed was searched for...
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Article
Animal Migraine Models for Drug Development: Status and Future Perspectives
Migraine is number seven in WHO’s list of all diseases causing disability and the third most costly neurological disorder in Europe. Acute attacks are treatable by highly selective drugs such as the triptans b...
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Article
Open AccessSuggested randomised, controlled trial with frovatriptan
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Article
Placebo response in migraine
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Open AccessOptimal balance of efficacy and tolerability of oral triptans and telcagepant: a review and a clinical comment
Dose–response curves for headaches relief and adverse events (AEs) are presented for five triptans: sumatriptan, zolmitriptan, naratriptan, almotriptan, and frovatriptan, and the CGRP antagonist telcagepant. T...
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Article
Open AccessSubcutaneous sumatriptan: results of a peculiar, unpublished, comparative, double-blind, randomised, and controlled trial
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Article
Open AccessAssociation between migraine, lifestyle and socioeconomic factors: a population-based cross-sectional study
To investigate whether sex-specific associations exist between migraine, lifestyle or socioeconomic factors. We distinguished between the subtypes migraine with aura (MA) and migraine without aura (MO). In 200...
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Pain Freedom at 2 Hours in Migraine after Telcagepant 300 mg
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Article
Low Efficacy of Transdermal Sumatriptan in Migraine
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Article
Open AccessAre the current IHS guidelines for migraine drug trials being followed?
In 2000, the Clinical Trials Subcommittee of the International Headache Society (IHS) published the second edition of its guidelines for controlled trials of drugs in migraine. The purpose of this publication ...
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Article
Open AccessNo effect of pure oxygen inhalation on headache induced by glyceryl trinitrate
Inhalation of hyperbaric oxygen has been used as an experimental treatment for migraine and pure oxygen is an established treatment for cluster headache. Intravenous glyceryl trinitrate (GTN) is an established...
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Open AccessCGRP in migraine
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Open AccessWhat can be learned from the history of recurrence in migraine? A comment
Recurrence was first recognised as a clinical problem in 1989 with the advent of sumatriptan. The history of recurrence in early sumatriptan randomised clinical trials is described. Recurrence has been ascribe...
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Article
Open AccessCalcitonin gene-related peptide in blood: is it increased in the external jugular vein during migraine and cluster headache? A review
The involvement of calcitonin gene-related peptide (CGRP) in migraine pathophysiological mechanisms is shown by the facts that CGRP can induce migraine and that two CGRP antagonists, olcegepant and telcagepant...
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Article
Open AccessNitric oxide-induced headache may arise from extracerebral arteries as judged from tolerance to isosorbide-5-mononitrate
Long-term exposure to organic nitrates influences different sections of the vascular bed heterogeneously. Continuous dosage of nitrates leads to the development of tolerance both to the vascular effects and to...
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Article
Open AccessPharmacogenomics and migraine: possible implications
Pharmacogenomics is the science about how inherited factors influence the effects of drugs. Drug response is always a result of mutually interacting genes with important modifications from environmental and co...
