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  1. No Access

    Article

    Pharmacokinetics of oxycodone hydrochloride and three of its metabolites after intravenous administration in Chinese patients with pain

    The aim of this study is to evaluate the pharmacokinetic profile of oxycodone and three of its metabolites, noroxycodone, oxymorphone and noroxymorphone after intravenous administration in Chinese patients wit...

    Guang-Tao Hao, Hai-Yan Zhou, Hong-Zhi Gao, Heng-Yan Qu… in Pharmacological Reports (2014)

  2. No Access

    Article

    Simultaneous Determination of Hydrocodone, and Its Two Metabolites in Human Plasma by HPLC–MS–MS

    A rapid, sensitive and specific assay method has been developed to simultaneously determine human plasma concentrations of hydrocodone and its metabolites, norhydrocodone, hydromorphone, using high-performance...

    Guang-Tao Hao, Yan Chen, Rui-Hua Dong, Heng-Yan Qu, Yu-Guang Liang… in Chromatographia (2011)

  3. No Access

    Article

    Pharmacokinetics and safety of a new bioengineered thrombolytic agent, human tissue urokinase type plasminogen activator in Chinese healthy volunteers

    The aim of our study was to investigate the pharmacokinetics and safety of human tissue urokinase type plasminogen activator (HTUPA) in healthy Chinese subjects after intravenous administration. Thirty-two sub...

    Yu-guang Liang, Peng Liu, Hong-zhi Gao… in European Journal of Drug Metabolism and Ph… (2011)

  4. No Access

    Article

    Bioanalysis of Cepharanthine by LC–ESI–MS–MS and Its Application to Pharmacokinetic Studies

    A sensitive liquid chromatography–electrospray ionization–tandem mass spectrometry (LC–ESI–MS–MS) method was developed and validated for the quantification of cepharanthine (CEP) in beagle dog plasma. The chro...

    Rui-Hua Dong, Zhong-Ze Fang, Hong-Zhi Gao, Guang-Tao Hao, Guang Liu… in Chromatographia (2011)