7 Result(s)
within
Gregory M. Vercellotti
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Article
Therapeutic strategies for sickle cell disease: towards a multi-agent approach
For over 100 years, clinicians and scientists have been unravelling the consequences of the A to T substitution in the β-globin gene that produces haemoglobin S, which leads to the systemic manifestations of s...
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Article
Open AccessThe endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria
The endothelial protein C receptor (EPCR) appears to play an important role in Plasmodium falciparum endothelial cell binding in severe malaria (SM). Despite consistent findings of elevated soluble EPCR (sEPCR) i...
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Article
Open AccessHemin inhibits NO production by IL-1β-stimulated human astrocytes through induction of heme oxygenase-1 and reduction of p38 MAPK activation
Heme oxygenase (HO)-1 has been shown to attenuate oxidative injury and reduce apoptosis. HO-1 can be induced by various stimuli released during cellular injury, such as heme. Deleterious free heme is degraded ...
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Article
Heme oxygenase-1 gene delivery by Slee** Beauty inhibits vascular stasis in a murine model of sickle cell disease
Increases in heme oxygenase-1 (HO-1) and administration of heme degradation products CO and biliverdin inhibit vascular inflammation and vasoocclusion in mouse models of sickle cell disease (SCD). In this stud...
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Article
Cytomegalovirus inhibits p53 nuclear localization signal function
Endothelial cells (EC) infected with the VHL strain of cytomegalovirus (CMV) are resistant to p53-mediated apoptosis, which may be relevant to EC dysfunction and atherogenesis. This resistance to apoptosis ma...
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Article
Impermeant stilbene disulfonic acids block chemotactic peptide receptor function on human granulocytes
Anion transport is important in a variety of cell functions. 4,4′-Diisothiocyanostilbene-2,2′-disulfonic acid (DIDS) and 4-acetamido-4′-isothiocyanostilbene2,2′-disulfonic acid (SITS) are two impermeant agents...
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Article
Ibuprofen inhibits granulocyte responses to inflammatory mediators
The use of nonsteroidal antiinflammatory agents to reduce myocardial infarct size has demonstrated a dichotomy between ibuprofen, which reduces myocardial infarct size, and aspirin, which does not. A feline mo...
