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  1. No Access

    Article

    Hippocampal 5-HT1A receptor binding is related to object–location memory in humans

    Animal studies suggest that serotonin, mediated by the 5-HT1A receptor, plays a key role in spatial learning and memory. The role of serotonin in spatial memory in humans has, however, been less well studied. Thi...

    Yifat Glikmann-Johnston, Michael M. Saling, Jian Chen… in Brain Structure and Function (2015)

  2. Article

    Open Access

    Pharmacodynamic analysis of tumour perfusion assessed by 15O-water-PET imaging during treatment with sunitinib malate in patients with advanced malignancies

    We evaluated pharmacodynamic changes in tumour perfusion using positron emission tomography (PET) imaging with 15O-water to assess biological response to sunitinib, a multitargeted tyrosine kinase inhibitor.

    Andrew M Scott, Paul L Mitchell, Graeme O'Keefe, Timothy Saunder… in EJNMMI Research (2012)

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  3. No Access

    Article

    Comparison of 11C-PiB and 18F-florbetaben for Aβ imaging in ageing and Alzheimer’s disease

    Amyloid imaging with 18F-labelled radiotracers will allow widespread use of this technique, facilitating research, diagnosis and therapeutic development for Alzheimer’s disease (AD). The purpose of this analysis ...

    Victor L. Villemagne, Rachel S. Mulligan… in European Journal of Nuclear Medicine and M… (2012)

  4. No Access

    Protocol

    Quantitative Approaches to Amyloid Imaging

    Alzheimer’s disease (AD), an irreversible, progressive neurodegenerative disorder clinically characterized by memory loss and cognitive decline, is the leading cause of dementia in the elderly, leading invaria...

    Victor L. Villemagne, Graeme O’Keefe, Rachel S. Mulligan… in Molecular Imaging (2011)

  5. Chapter and Conference Paper

    MR-Less High Dimensional Spatial Normalization of 11C PiB PET Images on a Population of Elderly, Mild Cognitive Impaired and Alzheimer Disease Patients

    β− amyloid (Aβ) plaques are one of the neuropathological hallmarks of Alzheimer’s disease (AD) and can be quantified using the marker ...

    Jurgen Fripp, Pierrick Bourgeat… in Medical Image Computing and Computer-Assis… (2008)

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  6. Chapter and Conference Paper

    Spline Based Inhomogeneity Correction for 11C-PIB PET Segmentation Using Expectation Maximization

    With the advent of biomarkers such as 11C-PIB and the increase in use of PET, automated methods are required for processing and analyzing datasets from research studies and in clinical settings. A common preproce...

    Parnesh Raniga, Pierrick Bourgeat… in Medical Image Computing and Computer-Assis… (2007)

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