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  1. No Access

    Article

    Induction of apoptosis and transient increase of phosphorylated MAPKs by diallyl disulfide treatment in human nasopharyngeal carcinoma CNE2 cells

    This study was undertaken to elucidate the effect of diallyl disulfide (DADS), an oil-soluble organosulfur compound found in garlic, in suppressing human nasopharyngeal carcinoma cells. A potent increase (of a...

    Yi Wei Zhang, Jun Wen, Jian Bo **ao, Simon G. Talbot… in Archives of Pharmacal Research (2006)

  2. No Access

    Article

    A preclinical model for noninvasive imaging of hypoxia-induced gene expression; comparison with an exogenous marker of tumor hypoxia

    Hypoxia is associated with tumor aggressiveness and is an important cause of resistance to radiation therapy and chemotherapy. Assays of tumor hypoxia could provide selection tools for hypoxia-modifying treatm...

    Bixiu Wen, Paul Burgman, Pat Zanzonico… in European Journal of Nuclear Medicine and M… (2004)

  3. No Access

    Article

    Ku affects the ATM-dependent S phase checkpoint following ionizing radiation

    Following exposure to genotoxic stress, proliferating cells actively slow down DNA replication through an S phase checkpoint to provide time for repair. The ATM-dependent pathway plays an important role in the...

    **ang-Yang Zhou, **ang Wang, Hongyan Wang, David J Chen, Gloria C Li… in Oncogene (2002)

  4. No Access

    Article

    Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

    THE DNA-dependent protein kinase (DNA-PK) is a mammalian serine/threonine kinase that is implicated in the repair of DNA double-strand breaks1–4, DNA replication1,5, transcription6–8, and V(D)J recombination9–12

    André Nussenzweig, Changhu Chen, Vera da Costa Soares, Mercedes Sanchez… in Nature (1996)

  5. No Access

    Article

    Ethanol-induced tolerance to heat and to adriamycin

    HEAT can induce a transient state of thermal tolerance so that mammalian cells surviving one exposure to hyperthermia are much more resistant to a subsequent heat exposure1,2. Studies of the combined and sequenti...

    GLORIA C. LI, GEORGE M. HAHN in Nature (1978)

  6. No Access

    Article

    Cellular inactivation by ultrasound

    THE lethal effect of ultrasound (US) on mammalian cells has received relatively little attention. Understandably, potential genetic aspects of US have been of prime concern to physicians who use US as a diagno...

    GLORIA C. LI, GEORGE M. HAHN, LEONARD J. TOLMACH in Nature (1977)