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  1. No Access

    Article

    Outcomes of symptomatic compared to asymptomatic recurrences in patients with glioblastoma multiforme (GBM)

    Glioblastoma multiforme (GBM) is a nearly uniformly fatal brain tumor with a median recurrence rate of 7 months and survival of 14 months after multimodality treatment. We sought to evaluate outcomes based on ...

    Arya Amini, Basel Altoos, Sana D. Karam… in Journal of Radiation Oncology (2016)

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    Article

    Hypofractionated-intensity modulated radiotherapy (hypo-IMRT) and temozolomide (TMZ) with or without bevacizumab (BEV) for newly diagnosed glioblastoma multiforme (GBM): a comparison of two prospective phase II trials

    To compare progression-free (PFS) and overall survival (OS) in patients treated in two consecutive phase II trials of hypofractionated-intensity modulated radiotherapy (hypo-IMRT) and temozolomide (TMZ) with o...

    Julie A. Carlson, Krishna Reddy, Laurie E. Gaspar, Douglas Ney… in Journal of Neuro-Oncology (2015)

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    Article

    Phase II trial of hypofractionated intensity-modulated radiation therapy combined with temozolomide and bevacizumab for patients with newly diagnosed glioblastoma

    Bevacizumab blocks the effects of VEGF and may allow for more aggressive radiotherapy schedules. We evaluated the efficacy and toxicity of hypofractionated intensity-modulated radiation therapy with concurrent...

    Douglas E. Ney, Julie A. Carlson, Denise M. Damek… in Journal of Neuro-Oncology (2015)

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    Article

    Prospective evaluation of health-related quality of life in patients with glioblastoma multiforme treated on a phase II trial of hypofractionated IMRT with temozolomide

    To report health-related quality of life (HRQOL) in glioblastoma (GBM) patients treated on a phase II trial of hypofractionated intensity-modulated radiotherapy (hypo-IMRT) with temozolomide (TMZ). GBM patient...

    Krishna Reddy, Laurie E. Gaspar, Brian D. Kavanagh… in Journal of Neuro-Oncology (2013)

  5. No Access

    Chapter

    Recurrent Malignant Gliomas

    Malignant gliomas are the most common brain tumor in adults. Each year, more than 14,000 new cases are diagnosed in the USA. Glioblastomas account for approximately 60–70% of malignant gliomas, anaplastic astr...

    Changhu Chen in Shaped Beam Radiosurgery (2011)

  6. No Access

    Article

    Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

    THE DNA-dependent protein kinase (DNA-PK) is a mammalian serine/threonine kinase that is implicated in the repair of DNA double-strand breaks1–4, DNA replication1,5, transcription6–8, and V(D)J recombination9–12

    André Nussenzweig, Changhu Chen, Vera da Costa Soares, Mercedes Sanchez… in Nature (1996)