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Article
Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis
The antimicrobial resistance crisis requires the introduction of novel antibiotics. The use of conventional broad-spectrum compounds selects for resistance in off-target pathogens and harms the microbiome. Thi...
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Article
New fluoroquinolones/nitric oxide donor hybrids: design, synthesis and antitubercular activity
New nitric oxide (NO) donating fluoroquinolones/nitrate ester hybrids were prepared and their structures were characterized by various spectroscopic and analytical tools. The release of NO from the prepared ni...
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Article
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla
The Hedgehog signalling pathway specifies tissue pattern in metazoan embryos. Intriguingly, the crystal structure of the human Sonic Hedgehog protein Shh complexed with a fragment of the cell surface protein C...
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Article
Structural basis for the methylation site specificity of SET7/9
Human SET7/9 is a protein lysine methyltransferase (PKMT) that methylates histone H3, the tumor suppressor p53 and the TBP-associated factor TAF10. To elucidate the determinants of its substrate specificity, w...