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  1. No Access

    Article

    Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis

    The antimicrobial resistance crisis requires the introduction of novel antibiotics. The use of conventional broad-spectrum compounds selects for resistance in off-target pathogens and harms the microbiome. Thi...

    Yu Imai, Glenn Hauk, Jeffrey Quigley, Libang Liang, Sangkeun Son… in Nature Chemical Biology (2022)

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    Article

    New fluoroquinolones/nitric oxide donor hybrids: design, synthesis and antitubercular activity

    New nitric oxide (NO) donating fluoroquinolones/nitrate ester hybrids were prepared and their structures were characterized by various spectroscopic and analytical tools. The release of NO from the prepared ni...

    Hossameldin A. Aziz, Gamal A. I. Moustafa, Samar H. Abbas… in Medicinal Chemistry Research (2019)

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    Article

    The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

    The Hedgehog signalling pathway specifies tissue pattern in metazoan embryos. Intriguingly, the crystal structure of the human Sonic Hedgehog protein Shh complexed with a fragment of the cell surface protein C...

    Jason S. McLellan, **aoyan Zheng, Glenn Hauk, Rodolfo Ghirlando, Philip A. Beachy… in Nature (2008)

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    Article

    Structural basis for the methylation site specificity of SET7/9

    Human SET7/9 is a protein lysine methyltransferase (PKMT) that methylates histone H3, the tumor suppressor p53 and the TBP-associated factor TAF10. To elucidate the determinants of its substrate specificity, w...

    Jean-François Couture, Evys Collazo, Glenn Hauk… in Nature Structural & Molecular Biology (2006)