21 Result(s)
within
Ginpreet Kaur
Biomedicine
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Article
A current review on P2X7 receptor antagonist patents in the treatment of neuroinflammatory disorders: a patent review on antagonists
Chronic inflammation is defined by an activated microglial state linked to all neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (a motor neuron dise...
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Article
Assessing the Clinical Correlation between Alzheimer's disease and Type-2 Diabetes Mellitus: Current Strategies and Emerging Perspectives
This article aims to provide a brief overview of novel therapeutic approaches for combating type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD).
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Chapter
Recent Update on Pyridoxine Derivatives as Anticancer Agents with Overview on Its Patents
Water-soluble vitamin B6 is made up of six molecules consisting of pyridoxine, pyridoxal, and its phosphorylated derivatives, each of which has a pyridine ring in its centre. Various epidemiological, in vivo, ...
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Article
Cannabinoid receptor 2 (CB2) agonists and l-arginine ameliorate diabetic nephropathy in rats by suppressing inflammation and fibrosis through NF-κβ pathway
Diabetic nephropathy (DN) is a condition that leads to end-stage chronic kidney disease characterized by inflammation and a deficiency of nitric oxide (NO). Cannabinoid receptor (CB2) activation by specific agoni...
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Article
Temozolomide and flavonoids against glioma: from absorption and metabolism to exosomal delivery
Patients with glioblastoma multiforme and anaplastic astrocytoma are treated with temozolomide. Although it has been demonstrated that temozolomide increases GBM patient survival, it has also been connected to...
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Article
Exploration of the Growing Therapeutic Potentials of Quercetin in Ovarian Cancer Management
This review aims to offer a comprehensive insight and a recent update into the etiology and pathophysiology of ovarian cancer, a recent update on the usage of quercetin for ovarian cancer management.
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Article
Nanoformulations of quercetin for controlled delivery: a review of preclinical anticancer studies
One of the well-studied older molecules, quercetin, is found in large quantities in many fruits and vegetables. Natural anti-oxidant quercetin has demonstrated numerous pharmacological properties in preclinica...
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Article
Dysbiosis and Alzheimer’s disease: role of probiotics, prebiotics and synbiotics
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by dementia and the accumulation of amyloid beta in the brain. Recently, microbial dysbiosis has been identified as one of the major factor...
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Article
Therapeutic potential of flavonoids in the management of obesity-induced Alzheimer’s disease: an overview of preclinical and clinical studies
Obesity is a global epidemic that affects people of all ages, genders, and backgrounds. It can lead to a plethora of disorders, including diabetes mellitus, renal dysfunction, musculoskeletal problems, metabol...
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Article
Genistein: a promising modulator of apoptosis and survival signaling in cancer
Genistein, a commonly occurring isoflavone, has recently gained popularity owing to its ever-expanding spectrum of pharmacological benefits. In addition to health benefits such as improved bone health and redu...
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Article
Challenges and Opportunities of Metal Chelation Therapy in Trace Metals Overload-Induced Alzheimer’s Disease
Essential trace metals like zinc (Zn), iron (Fe), and copper (Cu) play an important physiological role in the metabolomics and healthy functioning of body organs, including the brain. However, abnormal accumul...
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Chapter
Quercetin: A Promising Flavonoid for the Therapy of Cardiac Hypertrophy and Heart Failure Mediated by the Renin Angiotensin System
(RAS) plays an essential role in regulating levels in the body and maintaining cardiovascular homeostasis. However, overactivation of RAS leads to and cardiac overload, especially in the , causing . As ...
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Chapter
Anticancer Role of Natural Phenolic Acids by Targeting Angiotensin-Converting Enzyme (ACE)
Recently, it has become obvious that renin-angiotensin system (RAS) plays an important role in cancer progression through angiotensin converting enzyme (ACE), involving activation and upregulation of multiple ...
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Chapter
Role of Renin Angiotensin System in the Pathophysiology of Coronary Heart Disease: Advancements in Diagnosis, Therapy and Preventive Strategies
The incidence of (CHD) has been escalating over the years, and epidemiological data suggests that CHD causes nearly 17.9 million deaths worldwide annually. Myocardial infarction and stroke resulting from CHD...
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Article
Correction to: Lefamulin: a New Hope in the Field of Community-Acquired Bacterial Pneumonia
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Article
Lefamulin: a New Hope in the Field of Community-Acquired Bacterial Pneumonia
Community-acquired bacterial pneumonia (CABP) continues to be a worldwide health concern since it is the major cause of mortality and hospitalisation worldwide. Increased macrolide resistance among Streptococc...
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Article
Zebrafish as a Promising Tool for Modeling Neurotoxin-Induced Alzheimer’s Disease
Drug discovery and development for Alzheimer’s disease (AD) are complex and challenging due to the higher failure rate in the drug development process. The overproduction and deposition of Aβ senile plaque and...
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Chapter
Therapeutic Interventions of Endocannabinoid Signaling in Obesity-Related Cardiovascular Dysfunction
is a major risk factor involved in the progression . The aggravation is primarily linked to the release of pro-inflammatory cytokines. The endocannabinoid system (ECS) plays an important role in various di...
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Chapter
Role of Flavonoids in Obesity Induced Cardiovascular Dysfunction
Obesity is found to be a contributing risk factor for Cardiovascular Dysfunction (CVD), disease (CHD) is found to be linked to the release of several proinflammatory mediators. The fluctuation in the lev...
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Chapter
Pathophysiology of Obesity-Related Non-communicable Chronic Diseases and Advancements in Preventive Strategies
is characterized by an excessive accumulation of (WAT) causing increases in and (BMI >30 kg/m2). WAT stores energy and releases free fatty acids, but it is also a dynamic that triggers the production o...
