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Article
A current review on P2X7 receptor antagonist patents in the treatment of neuroinflammatory disorders: a patent review on antagonists
Chronic inflammation is defined by an activated microglial state linked to all neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (a motor neuron dise...
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Article
Simultaneous estimation of (α + β) boswellic acids, β-asarone, isoeugenol, 6-gingerol, and piperine in Majun Nisyan by high-performance thin-layer chromatography
Majun Nisyan (MJN) is a polyherbal formulation used in Unani medicine for its therapeutic efficacy against Nisyan (forgetfulness/dementia). In the current work, an effort was made to develop and validate a new hi...
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Article
Assessing the Clinical Correlation between Alzheimer's disease and Type-2 Diabetes Mellitus: Current Strategies and Emerging Perspectives
This article aims to provide a brief overview of novel therapeutic approaches for combating type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD).
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Chapter
Recent Update on Pyridoxine Derivatives as Anticancer Agents with Overview on Its Patents
Water-soluble vitamin B6 is made up of six molecules consisting of pyridoxine, pyridoxal, and its phosphorylated derivatives, each of which has a pyridine ring in its centre. Various epidemiological, in vivo, ...
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Chapter
Mitigation of Dementia and Alzheimer’s Disease with Lipophilic Vitamins and Their Derivatives: Preclinical and Clinical Evidence
Recent research has been exploring the link between vitamin deficiencies and the pathogenesis of neurodegenerative ailments such as cognition impairment, dementia, and Alzheimer’s disease (AD). Lipophilic vita...
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Article
Cannabinoid receptor 2 (CB2) agonists and l-arginine ameliorate diabetic nephropathy in rats by suppressing inflammation and fibrosis through NF-κβ pathway
Diabetic nephropathy (DN) is a condition that leads to end-stage chronic kidney disease characterized by inflammation and a deficiency of nitric oxide (NO). Cannabinoid receptor (CB2) activation by specific agoni...
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Article
Temozolomide and flavonoids against glioma: from absorption and metabolism to exosomal delivery
Patients with glioblastoma multiforme and anaplastic astrocytoma are treated with temozolomide. Although it has been demonstrated that temozolomide increases GBM patient survival, it has also been connected to...
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Chapter
Unraveling the Mechanisms of Hydrophilic Vitamins in Alzheimer’s and Parkinson’s: Preclinical and Clinical Evidence
(AD) (PD) are characterized by neuronal loss and cognitive and physical decline. The precise origins of remain unknown but oxidative damage, impaired proteosis are believed to be causal elements in dise...
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Article
Exploration of the Growing Therapeutic Potentials of Quercetin in Ovarian Cancer Management
This review aims to offer a comprehensive insight and a recent update into the etiology and pathophysiology of ovarian cancer, a recent update on the usage of quercetin for ovarian cancer management.
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Article
Nanoformulations of quercetin for controlled delivery: a review of preclinical anticancer studies
One of the well-studied older molecules, quercetin, is found in large quantities in many fruits and vegetables. Natural anti-oxidant quercetin has demonstrated numerous pharmacological properties in preclinica...
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Article
An LC-MS/MS Method for the Quantification of Major Biomarkers in “Majoon-e-Nisyan”—an Unani Polyherbal Formulation
Herbal medicines are considered to be safe and efficient and are widely used for the prevention and treatment of chronic disorders. However, quality control of these formulations and their standardization in t...
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Article
Dysbiosis and Alzheimer’s disease: role of probiotics, prebiotics and synbiotics
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by dementia and the accumulation of amyloid beta in the brain. Recently, microbial dysbiosis has been identified as one of the major factor...
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Article
Therapeutic potential of flavonoids in the management of obesity-induced Alzheimer’s disease: an overview of preclinical and clinical studies
Obesity is a global epidemic that affects people of all ages, genders, and backgrounds. It can lead to a plethora of disorders, including diabetes mellitus, renal dysfunction, musculoskeletal problems, metabol...
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Article
Genistein: a promising modulator of apoptosis and survival signaling in cancer
Genistein, a commonly occurring isoflavone, has recently gained popularity owing to its ever-expanding spectrum of pharmacological benefits. In addition to health benefits such as improved bone health and redu...
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Article
Open AccessArtificial intelligence in diagnosis and management of Huntington’s disease
Huntington’s disease is one of the rare neurodegenerative diseases caused because of genetic mutation of the Huntingtin gene. The major hallmarks of the condition include motor impairment, cognitive decline, a...
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Article
Metal nanoparticles in cancer: from synthesis and metabolism to cellular interactions
Nanotechnology has encouraged new and amended materials (metal nanoparticles) for therapeutic applications with specific prominence in healthcare. Metal nanoparticles (NPs) are versatile nanoscale entities, wi...
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Article
Challenges and Opportunities of Metal Chelation Therapy in Trace Metals Overload-Induced Alzheimer’s Disease
Essential trace metals like zinc (Zn), iron (Fe), and copper (Cu) play an important physiological role in the metabolomics and healthy functioning of body organs, including the brain. However, abnormal accumul...
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Article
Betanin mitigates scopolamine-induced cognitive impairment by restoring cholinergic function, boosting brain antioxidative status, and increasing BDNF level in the zebrafish model
Betalains obtained from Beta vulgaris (family Caryophyllales) are regularly consumed as part of the regular diet with medicinal benefits due to antioxidant and anti-inflammatory properties. The objective of this...
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Article
Immunotherapeutics in lung cancers: from mechanistic insight to clinical implications and synergistic perspectives
Lung cancer is one of the highly lethal forms of cancer whose incidence has worldwide rapidly increased over the past few decades. About 80–85% of all lung cancer cases constitute non-small cell lung cancer (N...
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Chapter
Quercetin: A Promising Flavonoid for the Therapy of Cardiac Hypertrophy and Heart Failure Mediated by the Renin Angiotensin System
(RAS) plays an essential role in regulating levels in the body and maintaining cardiovascular homeostasis. However, overactivation of RAS leads to and cardiac overload, especially in the , causing . As ...
