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Article
Open AccessThe relationship between low prolactin and type 2 diabetes
Prolactin (PRL) is secreted throughout life in men and women. At elevated levels, its physiological role in pregnancy and lactation, and pathological effects, are well known. However clinical implications of l...
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Article
Open AccessMarkov chain Monte Carlo Gibbs sampler approach for estimating haplotype frequencies among multiple malaria infected human blood samples
Malaria patients can have two or more haplotypes in their blood sample making it challenging to identify which haplotypes they carry. In addition, there are challenges in measuring the type and frequency of re...
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Approach for Genetic Studies
The genetic basis of disease started with the recognition of variations of patterns in disease risk and changes in risk among migrants, race/ethnicity, socioeconomic class, time trends, age effects, and gender...
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Article
Open AccessQuality of reporting of outcomes in phase III studies of pulmonary tuberculosis: a systematic review
Despite more than 60 years of clinical trials, tuberculosis (TB) still causes a high global burden of mortality and morbidity. Treatment currently requires multiple drugs in combination, taken over a prolonged...
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Article
Open AccessMarkov chain Monte Carlo and expectation maximization approaches for estimation of haplotype frequencies for multiply infected human blood samples
Haplotypes are important in anti-malarial drug resistance because genes encoding drug resistance may accumulate mutations at several codons in the same gene, each mutation increasing the level of drug resistan...
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Article
The VKORC1 Asp36Tyr variant and VKORC1 haplotype diversity in Ashkenazi and Ethiopian populations
The vitamin K epoxide reductase (VKORC1) is a key enzyme in the vitamin K cycle impacting various biological processes. VKORC1 genetic variability has been extensively studied in the context of warfarin pharmacog...
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Article
A genetic instrument for Mendelian randomization of fibrinogen
Mendelian randomization studies on fibrinogen commonly use a single genetic variant as an instrument, but this may explain only a small proportion of the total phenotypic variance. We examined the contribution...
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Article
Open AccessAPOE/C1/C4/C2 Gene Cluster Genotypes, Haplotypes and Lipid Levels in Prospective Coronary Heart Disease Risk Among UK Healthy Men
The role of common APOE variants on plasma lipids, particularly low density lipoprotein (LDL) levels, and coronary heart disease (CHD) risk is well known; the influence of variation in the other nearby apolipopro...
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Article
Physical activity is inversely associated with total homocysteine levels, independent of C677T MTHFR genotype and plasma B vitamins
The homocysteine level is considered to be a product of genetic and lifestyle interactions, mainly mutated methylenetetrahydrofolate reductase (MTHFR) and the intake of folate, vitamin B12 and pyridoxine, and ...
