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Article
Radiological findings in poisoning by synthetic cannabinoids adulterated with brodifacoum
Severe coagulopathy due to consumption of synthetic cannabinoids adulterated with brodifacoum, a long-acting anticoagulant, is an emerging worldwide hazard. Here, we review the spectrum of imaging findings in ...
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Article
Open AccessTrends in annual drug expenditure – a 16 year perspective of a public healthcare maintenance organization
Modern drug therapy accounts for a major share of health expenditure and challenges public provider resources. The objective of our study was to compare drug expenditure trends for ten major drug classes over ...
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Article
The VKORC1 Asp36Tyr variant and VKORC1 haplotype diversity in Ashkenazi and Ethiopian populations
The vitamin K epoxide reductase (VKORC1) is a key enzyme in the vitamin K cycle impacting various biological processes. VKORC1 genetic variability has been extensively studied in the context of warfarin pharmacog...
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Article
CYP2A6 genetic variation and dexmedetomidine disposition
There is a large interindividual variability in dexmedetomidine dose requirements for sedation of patients in intensive care units (ICU). Cytochrome P450 2A6 (CYP2A6) mediates an important route of dexmedetomi...
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Article
A Bayesian hierarchical nonlinear mixture model in the presence of artifactual outliers in a population pharmacokinetic study
The purpose of this study is to develop a statistical methodology to handle a large proportion of artifactual outliers in a population pharmacokinetic (PK) modeling. The motivating PK data were obtained from a...
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Article
Potent CYP2D6 Inhibiting drugs do not increase relapse rate in early breast cancer patients treated with adjuvant tamoxifen
Endoxifen, the most active metabolite of the prodrug tamoxifen, is produced by cytochrome P450 CYP2D6. Breast cancer patients treated with tamoxifen who have reduced CYP2D6 activity, related to either genetic ...
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Article
The α2C-adrenoceptor deletion322–325 variant and cold-induced vasoconstriction
Cold-induced vasoconstriction is mediated in part by selective enhancement of local α2C-adrenoceptor (α2C-AR) activity. A common insertion–deletion variant in the α2C-AR gene (ADRA2C del322–325) results in an app...
