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Article
Factors associated with early hydroxychloroquine-induced retinal toxicity in patients with systemic lupus erythematosus
Hydroxychloroquine is currently recommended for the treatment of systemic lupus erythematosus (SLE), but it can cause irreversible retinal toxicity. This study aimed to identify factors associated with early h...
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Article
Open AccessMusculoskeletal manifestations in children with Behçet’s syndrome: data from the AIDA Network Behçet’s Syndrome Registry
This study aims to describe musculoskeletal manifestations (MSM) in children with Behçet’s syndrome (BS), their association with other disease manifestations, response to therapy, and long-term prognosis. Data...
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Article
Open AccessAccrual of organ damage in Behçet’s syndrome: trajectory, associated factors, and impact on patients’ quality of life over a 2-year prospective follow-up study
This study aimed to investigate the trajectory of damage accrual, associated factors, and impact on health-related quality of life (HR-QoL) in a multicenter cohort of patients with Behçet’s syndrome (BS) over ...
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Article
Open AccessDevelopment and implementation of the AIDA International Registry for patients with Behçet’s disease
Purpose of the present paper is to point out the design, development and deployment of the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to pediatric and adult patients with Behçet’...
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Article
Obstetric outcomes in systemic sclerosis: looking inside the sealed box
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Article
Open AccessSystemic sclerosis and pregnancy outcomes: a retrospective study from a single center
Pregnancy in systemic sclerosis (SSc) patients is no more an infrequent event as it used to be, but literature data on pregnancy outcomes in women with SSc are scarce. The rate of preterm deliveries and intrau...
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Article
Open AccessElevated plasma levels of epithelial and endothelial cell markers in COVID-19 survivors with reduced lung diffusing capacity six months after hospital discharge
Some COVID-19 survivors present lung function abnormalities during follow-up, particularly reduced carbon monoxide lung diffusing capacity (DLCO). To investigate risk factors and underlying pathophysiology, we...
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Article
Open AccessThe presence of non-criteria manifestations negatively affects the prognosis of seronegative antiphospholipid syndrome patients: a multicenter study
Seronegative antiphospholipid syndrome (SN-APS) is often defined as the presence of APS criteria manifestations, negative antiphospholipid antibodies (aPL), and coexistence of APS non-criteria manifestations. ...
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Article
The extent of tubulointerstitial inflammation is an independent predictor of renal survival in lupus nephritis
Lupus nephritis (LN) is a major complication in patients with systemic lupus erythematosus (SLE). Tubulointerstitial injury is an inflammatory process that, if not attenuated, can promote renal damage. Despite...
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Article
Procoagulant microparticles are associated with arterial disease in patients with systemic lupus erythematosus
Microparticles (MPs) have been associated with inflammatory and thrombotic disease. High levels of MPs have been identified in patients with systemic lupus erythematosus (SLE) and associated with cardiovascula...
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Article
The impact of SARS-CoV-2 coronavirus infection in patients with systemic lupus erythematosus from a single center in Catalonia
To evaluate the incidence and characteristics of SARS-CoV-2 infection among patients with systemic lupus erythematosus (SLE) and to compare it to that described in the general population.
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Article
Open AccessDiscordance between patient and physician global assessment of disease activity in Behçet’s syndrome: a multicenter study cohort
To compare the patients’ and physician’s global assessment of disease activity in Behçet’s syndrome (BS) and investigate the frequency, magnitude, and determinants of potential discordance.
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Article
Precision medicine and the antiphospholipid syndrome: what is the future?
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Article
LAUDES Study: impact of digital ulcers on hand functional limitation, work productivity and daily activities, in systemic sclerosis patients
The objective of this study was to evaluate the impact of digital ulcers (DUs) in daily life of systemic sclerosis (SSc) Spanish patients. We developed a multicenter observational study to compare functional d...
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Article
Autoantibodies, elevated cytokines, and neurocognitive abnormalities in offspring of women with systemic lupus erythematosus: comparison with healthy controls
Research describes higher incidence of neurodevelopmental disorders and learning disabilities in offspring of women affected by lupus. Factors implied are pregnancy and delivery adversities and exposure to mat...
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Article
Open AccessBehçet’s disease and genetic interactions between HLA-B*51 and variants in genes of autoinflammatory syndromes
Behçet’s disease (BD) is an immune-mediated systemic disorder with a well-established genetic base. In a previous study, using a next generation sequencing approach, we found many rare variants and some functi...
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Article
Open AccessMutational profile of rare variants in inflammasome-related genes in Behçet disease: A Next Generation Sequencing approach
Behçet’s disease (BD) is an immune-mediated systemic disorder with a well-established association with HLA class I and other genes. BD has clinical overlap with many autoinflammatory diseases (AIDs). The aim o...
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Chapter
15th International Congress on Antiphospholipid Antibodies Task Force on Catastrophic Antiphospholipid Syndrome Report
Catastrophic antiphospholipid syndrome (CAPS) is a systemic disorder, resulting in both thrombotic and non-thrombotic events. Thrombosis manifests mainly as thrombotic microangiopathy (TMA), although large-ves...
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Chapter
Definition and Epidemiology of Antiphospholipid Syndrome
Accurate definition and epidemiology of a disease are the first steps to understand clinical and global burden of a disease. Although antiphospholipid syndrome (APS) has a clear definition for classification o...
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Article
Procoagulant microparticles are increased in patients with Behçet’s disease but do not define a specific subset of clinical manifestations
Microparticles (MP) are considered a key component in the haemostatic response. Beyond their in vitro procoagulant properties, a number of pieces of evidence points to procoagulant MP as efficient effectors in...