Inositol and Phosphoinositides
Metabolism and Regulation
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Article
Phospholipids inhibit proteolysis of protein kinase Cα by mM calcium-requiring calpain
The alpha isoform of protein kinase C (PKCα) is rapidly hydrolyzed by mM Ca2+-requiring calpain (calcium-activated neutral proteinase) under cell-free conditions (Shea et al, 1994, FEBS Lett. 350: 223). In the pr...
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Chapter
Molecular Geometries and Steric Energies of Phorbol 10, 11-Diacetate and 1, 2-Diacetylglycerol Molecules
Protein kinase C, an enzyme that is stimulated physiologically by diacylglycerol (DAG) and phospholipids in the presence of Ca2+, is involved in a novel cellular signaling system that is activated by the binding ...
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Article
Effects of pre-weaning undernutrition and post-weaning rehabilitation on polyphosphoinositide pools in rat brain regions
In order to assess the effects of undernutrition during the pre-weaning period on polyphosphoinositide (PolyPI) pools in rat cerebral cortex, brain stem, and cerebellum, dams were fed 5% (L−) or 22% (L+) protein ...
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Article
Effects of pre- and postweaning undernutrition on polyphosphoinositide pools in rat kidney
The effects of undernutrition on polyphosphoinositide levels in rat kidneys removed and frozen immediately after animal death or 10 min later were determined. Weanling (21-day-old) rats of dams fed a 5 or 22% ...
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Chapter and Conference Paper
Phospholipid Metabolism in Nervous Tissues: Modification of Precursor Incorporation and Enzyme Activities by Cationic Amphiphilic Drugs
Although the effects of individual drugs on the incorporation of precursors into lipids in vitro have been sporadically examined for thirty years or so, it is primarily during the last ten years that a substan...
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Book
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Article
Propranolol-induced inhibition of rat brain cytoplasmic phosphatidate phosphohydrolase
Propranolol, a cationic amphiphilic drug, caused enhanced incorporation of labeled precursor into phosphatidic acid and its metabolites in rat cerebral cortex mince, suggesting increased biosynthesis or reduce...
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Chapter
The Involvement of Lipids in Signal Transmission Across Cell Membranes of the Nervous System
Plasma membranes of cells in the nervous system have, in addition to specialized tasks characteristic for each cell type or particular cell region (such as nerve endings), the same functions as those of cells ...
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Article
Characteristics of the norepinephrine-stimulated phosphatidylinositol turnover in rat pineal cell dispersions
Dispersed rat pineal cells can be used for the study of the phosphatidylinositol effect. The response to (−)-norepinephrine of the incorporation of32Pi into phospholipids is linear with time and cell concentratio...
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Chapter
Accumulation and Metabolism of Phosphatidyl-CMP1 (CDP-Diglyceride) in the Pineal Gland of the Rat
The pineal gland receives its innervation from the superior cervical ganglion via adrenergic fibers. When intact rat pineal glands are incubated in vitro with 32Pi in the presence of the adrenergi...
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Article
Relationship of α-adrenergic receptors in rat pineal gland to drug-induced stimulation of phospholipid metabolism
NORADRENALINE produces increased uptake of 32Pi into acidic phospholipids in the nervous system1–4, and neurotransmitters and other stimuli do so in various tissues5–7. The rat pineal gland responds to noradrenal...
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Article
Modification by excessive heat of glyceryl phosphoryl ethanolamine on phenol-containing paper chromatograms
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Article
A simple micromethod for the collection of radioactive carbon dioxide in decarboxylation experiments
