Nutrition and Health
Volume 7 / 2013
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Article
Obesity: a 100 year perspective
This review has examined the scientific basis for our current understanding of obesity that has developed over the past 100 plus years. Obesity was defined as an excess of body fat. Methods of establishing pop...
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Book Series
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Chapter
Postscript: An Overview of Nutrition—Much Progress but Challenges Ahead
Nutrition in the twentieth century was mainly concerned with the individual substances found in food. At the same time it became firmly established that the disease pattern seen across the Western world is a d...
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Book
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Chapter
Obesity: A Disease of Overnutrition
Obesity is a serious worldwide problem that is increasing in prevalence. Obesity results from increased energy intake from food exceeding what is needed for daily energy expenditure over a considerable period ...
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Article
Blood DNA methylation at TXNIP and glycemic changes in response to weight-loss diet interventions: the POUNDS lost trial
Thioredoxin Interacting Protein (TXNIP) functions as a master regulator for glucose homeostasis. Hypomethylation at the 5’-cytosine-phosphate-guanine-3’ (CpG) site cg19693031 of TXNIP has been consistently relate...
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Chapter
Nutrition Guide for Physicians and Related Healthcare Professionals
Nutrition plays a key role, whether we know it or not, in everyone’s life and is a key element in health and well-being. This book is intended to provide the basic information needed by physicians and members ...
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Chapter
Postscript
Research studies over the last several decades convincingly demonstrate that the disease pattern seen across the Western world is a direct result of lifestyle and that diet plays a major role in this. This inf...
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Chapter
The Mediterranean Diet: A Healthy Dietary Plan
The concept of a Mediterranean diet can be attributed to Ancel Keys. His insights began the study of this dietary pattern and its many variations. Components of the Mediterranean diet have been described and c...
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Chapter
Obesity: Understanding and Achieving a Healthy Weight
Obesity is a chronic, relapsing, stigmatized disease process that is increasing in prevalence, affecting both adults and children. It is the result of a small positive energy imbalance from too much food or to...
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Book
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Article
Changes in gut-microbiota-related metabolites and long-term improvements in lipoprotein subspecies in overweight and obese adults: the POUNDS lost trial
Alterations in gut microbiota have been linked to obesity and impaired lipid metabolism. Lipoproteins are heterogeneous, and lipoprotein subspecies containing apolipoprotein C-III (apoCIII) have adverse associ...
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Article
Distinct genetic subtypes of adiposity and glycemic changes in response to weight-loss diet intervention: the POUNDS Lost trial
Obesity is a heterogeneous condition and distinct adiposity subtypes may differentially affect type 2 diabetes risk. We assessed relations between genetically determined subtypes of adiposity and changes in gl...
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Chapter
Therapeutic Management of Obesity
Obesity is a chronic relapsing disease process that is increasing in prevalence, affecting both adults and children. It is the result of a small positive energy imbalance from too much food, or too little acti...
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Article
In Memoriam: Alan Howard, MA, PhD, FRIC (1929–2020): as I knew him
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Article
Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesity
Consumption of high fat, high sugar (western) diets is a major contributor to the current high levels of obesity. Here, we used a multidisciplinary approach to gain insight into the molecular mechanisms underl...
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Article
Open AccessAssociations of Perfluoroalkyl substances with blood lipids and Apolipoproteins in lipoprotein subspecies: the POUNDS-lost study
The associations of perfluoroalkyl substance (PFAS) exposure with blood lipids and lipoproteins are inconsistent, and existing studies did not account for metabolic heterogeneity of lipoprotein subspecies. Thi...
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Article
Lessons Learned from the POUNDS Lost Study: Genetic, Metabolic, and Behavioral Factors Affecting Changes in Body Weight, Body Composition, and Cardiometabolic Risk
This paper reviews the genetic and non-genetic factors that provided predictions of, or were associated with, weight loss and other metabolic changes in the POUNDS Lost clinical trial of weight loss. This tria...
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Article
A circadian rhythm-related MTNR1B genetic variant modulates the effect of weight-loss diets on changes in adiposity and body composition: the POUNDS Lost trial
A common variant of the melatonin receptor 1B (MTNR1B) gene has been related to increased signaling of melatonin, a hormone previously associated with body fatness mainly through effects on energy metabolism. We ...
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Article
Non-traditional biomarkers and incident diabetes in the Diabetes Prevention Program: comparative effects of lifestyle and metformin interventions
We compared the associations of circulating biomarkers of inflammation, endothelial and adipocyte dysfunction and coagulation with incident diabetes in the placebo, lifestyle and metformin intervention arms of...
