Nutrition and Health
Volume 7 / 2013
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63 Result(s)
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David R. Jacobs Jr.
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Article
Open AccessImpaired artery elasticity predicts cardiovascular morbidity and mortality- A longitudinal study in the Vara-Skövde Cohort
It is still debated whether arterial elasticity provides prognostic information for cardiovascular risk beyond blood pressure measurements in a healthy population. To investigate the association between arteri...
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Article
Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification
Coronary artery calcification (CAC) is a measure of atherosclerosis and a well-established predictor of coronary artery disease (CAD) events. Here we describe a genome-wide association study of CAC in 22,400 p...
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Article
Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification
Coronary artery calcification (CAC), a measure of subclinical atherosclerosis, predicts future symptomatic coronary artery disease (CAD). Identifying genetic risk factors for CAC may point to new therapeutic a...
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Article
Inter-arm systolic blood pressure difference: non-persistence and association with incident cardiovascular disease in the Multi-ethnic Study of Atherosclerosis
We investigated inter-arm systolic blood pressure (sIAD) difference, reproducibility, and incident cardiovascular disease (CVD). We hypothesized that higher sIAD values have low prevalence and nonpersistence o...
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Book Series
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Chapter
Postscript: An Overview of Nutrition—Much Progress but Challenges Ahead
Nutrition in the twentieth century was mainly concerned with the individual substances found in food. At the same time it became firmly established that the disease pattern seen across the Western world is a d...
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Article
Cardiovascular risk factors predict age at death in 60-year follow-up of the Seven Countries Study
To study age at death (AD) and its determinants in cohorts of middle-aged men followed-up until extinction.
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Book
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Chapter
Methods in Nutrition Research
Many different research designs are available for investigating nutrition-related questions. Each one has strengths and weaknesses. Much nutrition-related research is carried out using epidemiological study de...
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Chapter
Challenges in Research in Nutritional Epidemiology
Diet is a complex aggregate of foods and behaviors. The food is constituted of a wide variety of intended and unintended chemicals which may act singly on human metabolism, but more likely act in groups in a s...
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Chapter
Food Synergy: A Paradigm Shift in Nutrition Science
A major focus of nutrition science has centered on identifying the various macronutrients, vitamins, and minerals and then investigating their mode of action. Many associations between diet and risk of disease...
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Article
Open AccessMarijuana use and DNA methylation-based biological age in young adults
Marijuana is the third most commonly used drug in the USA and efforts to legalize it for medical and recreational use are growing. Despite the increase in use, marijuana’s effect on aging remains understudied ...
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Article
Open AccessRelative contributions of six lifestyle- and health-related exposures to epigenetic aging: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
DNA methylation-based GrimAge acceleration (GrimAA) is associated with a wide range of age-related health outcomes including cardiovascular disease. Since DNA methylation is modifiable by external and behavior...
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Article
Open AccessUltrasensitive detection of salivary SARS-CoV-2 IgG antibodies in individuals with natural and COVID-19 vaccine-induced immunity
We assessed the feasibility of a highly sensitive immunoassay method based on single molecule array (Simoa) technology to detect IgG and IgA antibodies against SARS-CoV-2 spike protein receptor binding domain ...
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Article
Open AccessObesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium
In high-income countries, cancer is the leading cause of death among middle-aged adults. Prospective data on the effects of childhood risk exposures on subsequent cancer mortality are scarce.
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Article
Open AccessPlasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study
GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with atherosclerotic cardiovascular disease. However, the associations between early adulthood lipid levels and...
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Article
Open AccessBidirectional associations of accelerometer-derived physical activity and stationary behavior with self-reported mental and physical health during midlife
Moderate-to-vigorous intensity physical activity (MVPA) is associated with favorable self-rated mental and physical health. Conversely, poor self-rated health in these domains could precede unfavorable shifts ...
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Article
Associations of Acetylcholinesterase Inhibition Between Pesticide Spray Seasons with Depression and Anxiety Symptoms in Adolescents, and the Role of Sex and Adrenal Hormones on Gender Moderation
Cholinesterase inhibitor pesticides, especially organophosphates, are endocrine disruptors and a few existing studies have linked self-reports of exposure with increased depression and anxiety. Some evidence s...
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Article
Open AccessLung Function and Gene Expression of Pathogen Recognition Pathway Receptors: the Cardia Lung Study
Activation of toll-like receptors (TLR1, TLR5, TLR6) and downstream markers (CCR1, MAPK14, ICAM1) leads to increased systemic inflammation. Our objective was to study the association between the gene expression l...
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Article
Prediction of adult class II/III obesity from childhood BMI: the i3C consortium
Adult class II/III obesity (BMI ≥ 35 kg/m2) has significant adverse health outcomes. Early prevention and treatment are critical, but prospective childhood risk estimates are lacking. This study aimed to define t...
