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  1. Chapter

    Correction to: Transmissible Antibiotic Resistance

    Owing to an oversight on the part of Springer Fig. 11.2 and Fig. 11.3 of this chapter were initially published with errors. The error has been corrected and is reflected in both print and electronic versions.

    George A. Jacoby in Antimicrobial Resistance in the 21st Century (2018)

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    Protocol

    Study of Plasmid-Mediated Quinolone Resistance in Bacteria

    Plasmid-mediated quinolone resistance (PMQR) involves genes for proteins that protect the quinolone targets, an enzyme that inactivates certain quinolones as well as aminoglycosides, and pumps that efflux quin...

    George A. Jacoby in DNA Topoisomerases (2018)

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    Chapter

    Transmissible Antibiotic Resistance

    Bacteria have developed transmissible resistance to almost every antibiotic in clinical use, both synthetic compounds and natural products. The mechanisms are well understood: antibiotic inactivation, target a...

    George A. Jacoby in Antimicrobial Resistance in the 21st Century (2018)

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    Chapter

    Review of the Quinolone Family

    Quinolones are a class of potent, broad-spectrum synthetic agents with good bioavailability, oral and intravenous formulations, high serum and tissue levels, and a generally low incidence of side effects. Such...

    George A. Jacoby, David C. Hooper in Antibiotic Discovery and Development (2012)

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    Article

    Tackling antibiotic resistance

    The increasing levels of antibiotic resistance observed in clinical isolates, coupled with a lack of new drugs coming through the development pipeline, make the problem of antibiotic resistance a global crisis...

    Karen Bush, Patrice Courvalin, Gautam Dantas, Julian Davies… in Nature Reviews Microbiology (2011)

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    Chapter

    Plasmid-Mediated Quinolone Resistance

    In the 1990s quinolone resistance increased in parallel with increased quinolone utilization (1) and also with the emergence of plasmid-mediated quinolone resistance. The fi rst type of plasmid-mediated resist...

    George A. Jacoby in Antimicrobial Drug Resistance (2009)

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    Chapter

    History of Drug-Resistant Microbes

    Resistance to antimicrobial agents has been recognized since the dawn of the antibiotic era. Paul Ehrlich, the father of modern chemotherapy, observed that, during treatment of trypanosome infections, organism...

    George A. Jacoby in Antimicrobial Drug Resistance (2009)

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    Article

    Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase

    Antimicrobial-modifying resistance enzymes have traditionally been class specific, having coevolved with the antibiotics they inactivate. Fluoroquinolones, antimicrobial agents used extensively in medicine and...

    Ari Robicsek, Jacob Strahilevitz, George A Jacoby, Mark Macielag… in Nature Medicine (2006)

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    Article

    Molecular cloning and DNA homology of plasmid-mediated β-lactamase genes

    Molecular cloning of DNA fragments between 1.5 and 8kb from BamHI, EcoRI, HindIII, SalI, or Sau3A digests permitted the isolation of structural genes coding for TEM-1, ROB-1, OXA-1, OXA-3, OXA-4, OXA-5, PSE-1, PS...

    Roger C. Levesque, Antone A. Medeiros… in Molecular and General Genetics MGG (1987)

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    Article

    Control of the argECBH cluster in Escherichia coli

    The argECBH genes in Escherichia coli are tightly clustered, but argE is not controlled coordinately with argCBH. Furthermore, while nonsense mutations have been isolated in argC and argB which are polar for argH

    George A. Jacoby in Molecular and General Genetics MGG (1972)