5 Result(s)
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Alvaro Avivar-Valderas
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Article
Open AccessHuman adipose mesenchymal stem cells modulate myeloid cells toward an anti-inflammatory and reparative phenotype: role of IL-6 and PGE2
Mesenchymal stem cells (MSCs) activate the endogenous immune regulatory system, inducing a therapeutic effect in recipients. MSCs have demonstrated the ability to modulate the differentiation of myeloid cells ...
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Article
Correction: Corrigendum: Mechanism of early dissemination and metastasis in Her2+ mammary cancer
Nature 540, 588–592 (2016); doi:10.1038/nature20609 In Extended Data Fig. 4g of this Letter, the image showing the rabbit IgG control (top image) was incorrect. This image was mistakenly duplicated and cropped...
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Article
Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments
Hypoxia is a poor-prognosis microenvironmental hallmark of solid tumours, but it is unclear how it influences the fate of disseminated tumour cells (DTCs) in target organs. Here we report that hypoxic HNSCC an...
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Mechanism of early dissemination and metastasis in Her2+ mammary cancer
Two related papers show that cells disseminated from malignant lesions at early time points during tumorigenesis can contribute to metastases at distant organs and provide insights into the molecular basis of ...
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Article
Open AccessInhibition of eIF2α dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis
The ErbB2/Her2/Neu receptor tyrosine kinase is amplified in ~30% of human breast cancers. Phosphorylation of the translation initiation factor, eIF2α inhibits global protein synthesis and activates a stress si...
