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  1. Article

    Open Access

    Type 2 diabetes and cardiometabolic risk may be associated with increase in DNA methylation of FKBP5

    Subclinical hypercortisolism and hypothalamic-pituitary-adrenal (HPA) axis dysfunction are associated with type 2 diabetes (T2DM), cardiovascular disease, and metabolic dysfunction. Intronic methylation of FKBP5 ...

    Robin Ortiz, Joshua J. Joseph, Richard Lee, Gary S. Wand… in Clinical Epigenetics (2018)

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  2. No Access

    Article

    History of childhood adversity is positively associated with ventral striatal dopamine responses to amphetamine

    Childhood exposure to severe or chronic trauma is an important risk factor for the later development of adult mental health problems, such as substance abuse. Even in nonclinical samples of healthy adults, per...

    Lynn M. Oswald, Gary S. Wand, Hiroto Kuwabara, Dean F. Wong… in Psychopharmacology (2014)

  3. No Access

    Article

    Volunteerism and self-selection bias in human positron emission tomography neuroimaging research

    Scientists have known for decades that persons who volunteer for behavioral research may be different from those who decline participation and that characteristics differentiating volunteers from non-volunteer...

    Lynn M. Oswald, Gary S. Wand, Shijun Zhu, Victoria Selby in Brain Imaging and Behavior (2013)

  4. No Access

    Article

    Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adults

    Chronic dysregulation of hypothalamus–pituitary–adrenal (HPA) axis activity is related to several neuropsychiatric disorders. Studies suggest that cortisol response to stress has a strong genetic etiology, and...

    Pamela Belmonte Mahon, Peter P. Zandi, James B. Potash… in Psychopharmacology (2013)

  5. No Access

    Article

    A measure of glucocorticoid load provided by DNA methylation of Fkbp5 in mice

    Given the contribution of cortisol dysregulation to neuropsychiatric and metabolic disorders, it is important to be able to accurately compute glucocorticoid burden, a measure of allostatic load. One major pro...

    Richard S. Lee, Kellie L. K. Tamashiro, **aoju Yang, Ryan H. Purcell… in Psychopharmacology (2011)

  6. No Access

    Article

    Polymorphism of the gene encoding the alpha subunit of the stimulatory G-protein of adenylyl cyclase (GNAS1)

    A two-allele polymorphism of the human gene encoding for the alpha subunit of the guanine nucleotide-binding protein is described.

    Claire Waltman, Michael A. Levine, William F. Schwindinger, Gary S. Wand in Human Genetics (1994)

  7. No Access

    Chapter

    Alterations in Hypothalamo-Hypophyseal Function by Ethanol

    Alcoholism is a disorder characterized by a persistent and progressive pattern of ethanol ingestion which, over time, results in the loss of control over drinking and a narrowing of interests in activities oth...

    Gary S. Wand, Janice C. Froehlich in Neuroendocrine Perspectives (1991)