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Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine
The Janus tyrosine kinase (JAK) family of non-receptor tyrosine kinases includes four isoforms (JAK1, JAK2, JAK3, and TYK2) and is responsible for signal transduction downstream of diverse cytokine receptors. ...
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Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine
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Author Correction: Defining the consequences of genetic variation on a proteome-wide scale
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Article
Open AccessAge-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes
Glaucoma is a chronic disease that shares many similarities with other neurodegenerative disorders of the central nervous system. This study was designed to evaluate the association between glaucoma and other ...
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Article
The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival
The cyclin D3–CDK6 kinase complex, which is overactive in some cancers, inhibits two key glycolysis enzymes and thereby enhances the levels of antioxidants in cells, promoting tumour cell survival.
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Article
G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells
Progression of mammalian cells through the G1 and S phases of the cell cycle is driven by the D-type and E-type cyclins. According to the current models, at least one of these cyclin families must be present t...
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Defining the consequences of genetic variation on a proteome-wide scale
Genetic variation modulates protein expression through both transcriptional and post-transcriptional mechanisms. To characterize the consequences of natural genetic diversity on the proteome, here we combine a...
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Article
Open AccessInduction of virulence factors in Giardia duodenalis independent of host attachment
Giardia duodenalis is responsible for the majority of parasitic gastroenteritis in humans worldwide. Host-parasite interaction models in vitro provide insights into disease and virulence and help us to understand...
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Applications of Quantitative Proteomics in Plant Research
Over the past two decades, we witnessed significant technological advances in Proteomics. Methodology and instrumentation have developed remarkably and proteomics has become a priority field of research in bio...
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Article
Erratum: A mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides
Nat. Biotechnol. 10.1038/nbt.3267; corrected online 18 June 2015 In the version of this article initially published online, in Figure 3c, the label “unidentified b-type ions” should have been deleted, and in F...
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Article
A mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides
In shotgun proteomics experiments, modified peptides account for a large part of the unassigned spectra and can be identified using ultra-tolerant database searches.