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    Article

    Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine

    The Janus tyrosine kinase (JAK) family of non-receptor tyrosine kinases includes four isoforms (JAK1, JAK2, JAK3, and TYK2) and is responsible for signal transduction downstream of diverse cytokine receptors. ...

    Madeline E. Kavanagh, Benjamin D. Horning, Roli Khattri in Nature Chemical Biology (2022)

  2. Article

    Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine

    Madeline E. Kavanagh, Benjamin D. Horning, Roli Khattri in Nature Chemical Biology (2022)

  3. Article

    Author Correction: Defining the consequences of genetic variation on a proteome-wide scale

    Joel M. Chick, Steven C. Munger, Petr Simecek, Edward L. Huttlin, Kwangbom Choi in Nature (2022)

  4. Article

    Open Access

    Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes

    Glaucoma is a chronic disease that shares many similarities with other neurodegenerative disorders of the central nervous system. This study was designed to evaluate the association between glaucoma and other ...

    Mehdi Mirzaei, Veer B. Gupta, Joel M. Chick, Todd M. Greco, Yunqi Wu in Scientific Reports (2017)

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    Article

    The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival

    The cyclin D3–CDK6 kinase complex, which is overactive in some cancers, inhibits two key glycolysis enzymes and thereby enhances the levels of antioxidants in cells, promoting tumour cell survival.

    Haizhen Wang, Brandon N. Nicolay, Joel M. Chick, Xueliang Gao, Yan Geng, Hong Ren in Nature (2017)

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    Article

    G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells

    Progression of mammalian cells through the G1 and S phases of the cell cycle is driven by the D-type and E-type cyclins. According to the current models, at least one of these cyclin families must be present t...

    Lijun Liu, Wojciech Michowski, Hiroyuki Inuzuka, Kouhei Shimizu in Nature Cell Biology (2017)

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    Article

    Defining the consequences of genetic variation on a proteome-wide scale

    Genetic variation modulates protein expression through both transcriptional and post-transcriptional mechanisms. To characterize the consequences of natural genetic diversity on the proteome, here we combine a...

    Joel M. Chick, Steven C. Munger, Petr Simecek, Edward L. Huttlin, Kwangbom Choi in Nature (2016)

  8. Article

    Open Access

    Induction of virulence factors in Giardia duodenalis independent of host attachment

    Giardia duodenalis is responsible for the majority of parasitic gastroenteritis in humans worldwide. Host-parasite interaction models in vitro provide insights into disease and virulence and help us to understand...

    Samantha J. Emery, Mehdi Mirzaei, Daniel Vuong, Dana Pascovici in Scientific Reports (2016)

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    Chapter

    Applications of Quantitative Proteomics in Plant Research

    Over the past two decades, we witnessed significant technological advances in Proteomics. Methodology and instrumentation have developed remarkably and proteomics has become a priority field of research in bio...

    Mehdi Mirzaei, Yunqi Wu, David Handler, Tim Maher in Agricultural Proteomics Volume 1 (2016)

  10. Article

    Erratum: A mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides

    Nat. Biotechnol. 10.1038/nbt.3267; corrected online 18 June 2015 In the version of this article initially published online, in Figure 3c, the label “unidentified b-type ions” should have been deleted, and in F...

    Joel M Chick, Deepak Kolippakkam, David P Nusinow, Bo Zhai in Nature Biotechnology (2015)

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    Article

    A mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides

    In shotgun proteomics experiments, modified peptides account for a large part of the unassigned spectra and can be identified using ultra-tolerant database searches.

    Joel M Chick, Deepak Kolippakkam, David P Nusinow, Bo Zhai in Nature Biotechnology (2015)