37 Result(s)

Article

Polygenic risk has an impact on the structural plasticity of hippocampal subfields during aerobic exercise combined with cognitive remediation in multi-episode schizophrenia

Preliminary studies suggest that, besides improving cognition, aerobic exercise might increase hippocampal volume in schizophrenia patients; however, results are not consistent. Individual mechanisms of volume...

S Papiol, D Popovic, D Keeser, A Hasan, T Schneider-Axmann… in Translational Psychiatry (2017)

Article

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipola...

S H Witt, F Streit, M Jungkunz, J Frank, S Awasthi… in Translational Psychiatry (2017)

Article

Genetic effects influencing risk for major depressive disorder in China and Europe

Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30–40%), extensive heterogeneity...

T B Bigdeli, S Ripke, R E Peterson, M Trzaskowski, S-A Bacanu… in Translational Psychiatry (2017)

Article

Genetik des Morbus Crohn und der Colitis ulcerosa

Modernste Technologien der genetischen Forschung bieten der Medizin einen ganz neuen Zugangsweg zur Entdeckung von genetischen Krankheitsursachen. Innerhalb der letzten 15 Jahre wurden die genetischen Untersuc...

F. Degenhardt, Prof. Dr. A. Franke in Der Gastroenterologe (2017)

Article

Functional neuroimaging effects of recently discovered genetic risk loci for schizophrenia and polygenic risk profile in five RDoC subdomains

Recently, 125 loci with genome-wide support for association with schizophrenia were identified. We investigated the impact of these variants and their accumulated genetic risk on brain activation in five neuro...

S Erk, S Mohnke, S Ripke, T A Lett, I M Veer, C Wackerhagen… in Translational Psychiatry (2017)

Article

Rare SHANK2 variants in schizophrenia

S Peykov, S Berkel, F Degenhardt, M Rietschel, M M Nöthen… in Molecular Psychiatry (2015)

Article

Identification and functional characterization of rare SHANK2 variants in schizophrenia

Recent genetic data on schizophrenia (SCZ) have suggested that proteins of the postsynaptic density of excitatory synapses have a role in its etiology. Mutations in the three SHANK genes encoding for postsynaptic...

S Peykov, S Berkel, M Schoen, K Weiss, F Degenhardt, J Strohmaier… in Molecular Psychiatry (2015)

Article

Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder

Bipolar disorder (BD) is a severe and highly heritable neuropsychiatric disorder with a lifetime prevalence of 1%. Molecular genetic studies have identified the first BD susceptibility genes. However, the dise...

A J Forstner, A Hofmann, A Maaser, S Sumer, S Khudayberdiev… in Translational Psychiatry (2015)

Article

Erratum: Identification of increased genetic risk scores for schizophrenia in treatment-resistant patients

Correction to: Molecular Psychiatry (2015) 20, 150–151; doi:10.1038/mp.2014.56; published online 3 June 2014 Following publication of this paper, the authors noticed an error regarding the direction of the ass...

J Frank, M Lang, S H Witt, J Strohmaier, D Rujescu, S Cichon… in Molecular Psychiatry (2015)

Article

Identification of increased genetic risk scores for schizophrenia in treatment-resistant patients

J Frank, M Lang, S H Witt, J Strohmaier, D Rujescu, S Cichon… in Molecular Psychiatry (2015)

Article

Investigation of manic and euthymic episodes identifies state- and trait-specific gene expression and STAB1 as a new candidate gene for bipolar disorder

Bipolar disorder (BD) is a highly heritable psychiatric disease characterized by recurrent episodes of mania and depression. To identify new BD genes and pathways, the present study employed a three-step appro...

S H Witt, D Juraeva, C Sticht, J Strohmaier, S Meier… in Translational Psychiatry (2014)

Article

Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deficit/hyperactivity disorder

Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental disorder. Genetic loci have not yet been identified by genome-wide association studies. Rare copy number variati...

I Jarick, A-L Volckmar, C Pütter, S Pechlivanis, T T Nguyen… in Molecular Psychiatry (2014)

Article

The biology of malignant breast tumors has an impact on the presentation in ultrasound: an analysis of 315 cases

The aim of this study was to evaluate the relation of some ultrasound morphological parameters to biological characteristics in breast carcinoma.

S Wojcinski, N Stefanidou, P Hillemanns, F Degenhardt in BMC Women's Health (2013)

Article

Duplications in RB1CC1 are associated with schizophrenia; identification in large European sample sets

Schizophrenia (SCZ) is a severe and debilitating neuropsychiatric disorder with an estimated heritability of ~80%. Recently, de novo mutations, identified by next-generation sequencing (NGS) technology, have been...

F Degenhardt, L Priebe, S Meier, L Lennertz, F Streit, S H Witt… in Translational Psychiatry (2013)

Article

Genome-wide significant association between a ‘negative mood delusions’ dimension in bipolar disorder and genetic variation on chromosome 3q26.1

Research suggests that clinical symptom dimensions may be more useful in delineating the genetics of bipolar disorder (BD) than standard diagnostic models. To date, no study has applied this concept to data fr...

S Meier, M Mattheisen, E Vassos, J Strohmaier, J Treutlein… in Translational Psychiatry (2012)

Article

Replication of functional serotonin receptor type 3A and B variants in bipolar affective disorder: a European multicenter study

Serotonin type 3 receptors (5-HT₃) are involved in learning, cognition and emotion, and have been implicated in various psychiatric phenotypes. However, their contribution to the pathomechanism of these disorders...

C Hammer, S Cichon, T W Mühleisen, B Haenisch, F Degenhardt… in Translational Psychiatry (2012)