![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Effect of Heat Treatment Conditions on Retained Austenite and Corrosion Resistance of the X190CrVMo20-4-1 Stainless Steel
In the present work the microstructural characterization of the powder-metallurgy X190CrVMo20-4-1 has been performed and correlated with its corrosion properties. The martensitic stainless steel was hardened a...
-
Article
Paranoid Thoughts in Adolescents with Social Anxiety Disorder
Recently, social anxiety disorder (SAD) and paranoia have been demonstrated to be closely related. However, data were primarily drawn from adult community samples or patients with schizophrenia. The present s...
-
Article
Listeria meningoencephalitis and anti-GQ1b antibody syndrome
We report the first case of Listeria monocytogenes meningoencephalitis associated with anti-GQ1b antibody syndrome in an immunocompetent adult. A prompt diagnosis, made thanks to the multidisciplinary contributio...
-
Article
Instrumental methods for professional and amateur collaborations in planetary astronomy
Amateur contributions to professional publications have increased exponentially over the last decades in the field of planetary astronomy. Here we review the different domains of the field in which collaborati...
-
Article
Prospective study of EGFR intron 1 (CA)n repeats variants as predictors of benefit from cetuximab and irinotecan in chemo-refractory metastatic colorectal cancer (mCRC) patients
The number of CA tandem repeats (CA)n in a highly polymorphic region of EGFR (epidermal growth factor receptor) intron 1 may affect gene transcription; the potential impact of allelic variants on the efficacy of ...
-
Article
Open AccessHistopathologic evaluation of liver metastases from colorectal cancer in patients treated with FOLFOXIRI plus bevacizumab
The FOLFOXIRI regimen produces a high rate of radiological and histopathological responses. Bevacizumab added to chemotherapy showed an improvement in pathological response and necrosis of colorectal liver met...
-
Article
Open AccessPharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer
The identification of molecular and genetic markers to predict or monitor the efficacy of bevacizumab (BV) represents a key issue in the treatment of metastatic colorectal cancer (mCRC).
-
Article
Open AccessKRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer
KRAS codons 12 and 13 mutations predict resistance to anti-EGFR monoclonal antibodies (moAbs) in metastatic colorectal cancer. Also, BRAF V600E mutation has been associated with resistance. Additional KRAS mutati...
-
Article
Investigation of BRAFand CTNNB1 activating mutations in adrenocortical tumors
Background: Activating mutations of the BRAF oncogene play a central role in the development of various cancer types, but their role in human adrenocortical tumors is unknown. At variance...
-
Article
Open AccessA multicenter phase II study of the combination of oxaliplatin, irinotecan and capecitabine in the first-line treatment of metastatic colorectal cancer
The triple drug combination consisting of irinotecan, oxaliplatin and 5-fluorouracil (FOLFOXIRI) has demonstrated higher activity and efficacy compared to the doublet FOLFIRI. 5-Fluorouracil could be substitut...
-
Article
A dose finding and pharmacokinetic study of capecitabine in combination with oxaliplatin and irinotecan in metastatic colorectal cancer
The GONO-FOLFOXIRI regimen demonstrated higher activity and efficacy than FOLFIRI in metastatic colorectal cancer patients. The aim of this study was to determine the maximum tolerated dose of capecitabine, in...
-
Article
Variations in the interleukin-1 receptor antagonist gene impact on survival of patients with advanced colorectal cancer
The interleukin-1 receptor antagonist (IL-1RA) cytokine is thought to counteract tumor angiogenesis/metastasis. Two single nucleotide polymorphisms in the IL-1RA gene (rs4251961 T/C and rs579543 C/T) influence IL...
-
Article
Psychotropic Drug Used for Attention-Deficit/Hyperactivity Disorder (ADHD) in Italian Children and Adolescent Population
-
Article
Open AccessLiver-only metastatic colorectal cancer patients and thymidylate synthase polymorphisms for predicting response to 5-fluorouracil-based chemotherapy
We investigated the association between thymidylate synthase (TS) germline polymorphisms and response to 5-fluorouracil-based chemotherapy in 80 patients with liver-only metastatic colorectal cancer (MCRC). The t...
-
Article
Open AccessA pharmacokinetic and pharmacodynamic study on metronomic irinotecan in metastatic colorectal cancer patients
The pharmacokinetics (PK) and pharmacodynamics (PD) of metronomic irinotecan have not been studied in cancer patients. The aim of the study is to investigate the PK/PD profile of irinotecan/SN-38 administered ...
-
Article
Detection of polyomaviruses and herpesviruses in human adrenal tumors
The presence of polyomaviruses and herpesviruses in adrenal tumors and their role in adrenal tumorigenesis has never been investigated, even though the adrenal gland seems to be a preferential site of infectio...
-
Article
The role of 21-hydroxylase in the pathogenesis of adrenal masses: Review of the literature and focus on our own experience
An exaggerated response of 17-hydroxyprogesterone (17-OHP) to exogenous ACTH stimulation has been found in 30 to 70% of patients with incidentally discovered adrenal tumors, supporting the concept that congeni...
-
Article
Charon's size and an upper limit on its atmosphere from a stellar occultation
Stellar occultations, when a Solar System object passes between us and a star and blocks its light, are eagerly awaited by astronomers as they provide a chance to make measurements that are not normally possib...
-
Article
Fatigue in Parkinson’s disease
Fatigue is a recognized problem in Parkinson’s disease and other clinical conditions. We characterized this symptom in 19 patients and 19 age- and sex-matched controls, using the Multidimensional Fatigue Inven...
-
Article
Frequency of familial aggregation in primary adult-onset cranial cervical dystonia
Family history of definite/probable dystonia was studied in 36 probands with primary adult-onset cranial/cervical dystonia. Of the 157 relatives who were examined, 8 from 7 families and 11 from 10 families wer...