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Article
Application of Photofrin II as a specific radiosensitising agent in patients with bladder cancer—a report of two cases
Background: the effect of ionizing radiation on tumour tissues can be optimised by adding radiosensitising agents to enhance tumour inactivation. Photofrin II has been approved as a photosensitising agent for ...
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Article
Open AccessHigh efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma
Benzoporphyrin derivative monoacid ring A (verteporfin, BPD-MA) when intravenously injected (5.5 μmol kg–1) to C57/BL6 mice bearing a subcutaneously transplanted B1 melanoma gave a maximal accumulation in the tum...
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Article
Laser-induced fluorescence studies of the biodistribution of carotenoporphyrins in mice
The biodistribution of two recently developed tumour markers, trimethylated (CP(Me)3) and trimethoxylated (CP(OMe)3) carotenoporphyrin, was investigated by means of laser-induced fluorescence (LIF) after i.v. ...
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Article
Tumour-localising and -photosensitising properties of a novel zinc(II) octadecylphthalocyanine
1,4,8,11,15,18,22,25-Octadecylphthalocyaninato zinc(II), ZnODPc, incorporated into a Cremophor emulsion, was assayed for its pharmacokinetic and phototherapeutic properties in Balb/c mice bearing an intramuscu...
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Chapter and Conference Paper
Photodynamic Therapy of B16 Pigmented Melanoma with Si(IV)Naphthalocyanine Photoactivated by Diode Laser
Melanotic malignant melanoma represents a major cause of death among skin neoplasias and its incidence is steadily increasing in Western world probably owing to changes in lifestyle which favour brief but inte...
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Article
Effect of axial ligation and delivery system on the tumour-localising and -photosensitising properties of Ge(IV)-octabutoxy-phthalocyanines
Four Ge(IV)-octabutoxy-phthalocyanines (GePcs) bearing two alkyl-type axial ligands were assayed for their pharmacokinetic properties and phototherapeutic efficiency in Balb/c mice bearing an intramuscularly t...
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Article
Photodynamic therapy of experimental tumours with Zn(II)-phthalocyanine and pulsed laser irradiation
The effectiveness of a pulsed dye laser (673 nm) for photodynamic therapy (PDT) of tumours in the presence of Zn(II)-phthalocyanine (ZnPc) was evaluated using Lewis lung carcinoma-bearing mice. The tumours wer...
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Article
Laser-induced fluorescence in malignant and normal tissue in mice injected with two different carotenoporphyrins
Laser-induced fluorescence (LIF) was used to characterise the localisation of an intravenously administered trimethylated carotenoporphyrin [CP(Me)3] and a trimethoxylated carotenoporphyrin [CP(OMe)3] in an in...
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Article
In vivo fluorescence and photodynamic activity of zinc phthalocyanine administered in liposomes
Zinc(II) phthalocyanine, a hydrophobic photosensitiser, was incorporated in unilamellar liposomes and studied in vivo for fluorescence kinetics and photodynamic activity. An observation chamber mounted in a do...
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Article
CGP 55398, a liposomal Ge(IV) phthalocyanine bearing two axially ligated cholesterol moieties: a new potential agent for photodynamic therapy of tumours
Ge(IV) phthalocyanine (GePc) with two axially ligated cholesterol moieties was prepared by chemical synthesis and incorporated in a monomeric state into small unilamellar liposomes (CGP 55398). Upon photoexcit...
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Article
Carotenoporphyrins as selective photodiagnostic agents for tumours
The covalent binding of a carotene moiety to one phenyl ring and meso-tetraphenyl-substituted porphyrins (see Figure 1) efficiently quenches the photosensitising activity of the porphyrin while a relatively la...
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Article
Tumour-localising and -photosensitizing properties of liposome-delivered Ge(IV)-octabutoxy-phthalocyanine
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Chapter
A Comparison of Laser and Arc-Lamp Spectroscopic Systems for In-Vivo Pharmacokinetic Measurements of Photosensitizers Used in Photodynamic Therapy
The treatment of neoplastic tissue using photodynamic therapy is currently undergoing a worldwide concerted research effort, enabling human treatment of such tissue using the drug hematoporphyrin derivative (H...
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Chapter
Zinc(II)-Phthalocyanine as a Second-Generation Photosensitizing Agent in Tumour Phototherapy
The use of phthalocyanines as phototherapeutic agents for tumours was first proposed in 1985 (Ben-Hur and Rosenthal, 2985). A variety of cellular and animal studies, (for a review see Spikes, 1986;Tralau et al...
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Article
Liposome- or LDL-administered Zn(II)-phthalocyanine as a photodynamic agent for tumours III. Effect of cholesterol on pharmacokinetic and phototherapeutic properties
The pharmacokinetic behaviour of Zn-phthalocyanine (Zn-Pc) has been studied in mice bearing a transplanted MS-2 fibrosarcoma using liposomes of dipalmitoyl-phosphatidylcholine containing 15% moles of cholester...
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Article
Liposome-delivered Si(IV)-naphthalocyanine as a photodynamic sensitiser for experimental tumours: pharmacokinetic and phototherapeutic studies
The pharmacokinetic behaviour and phototherapeutic effectiveness of bis(di-isobutyloctadecylsil-oxy)-2,3-naphthalocyanatosilicon (iso-BOSiNc) incorporated into dipalmitoyl-phosphatidylcholine (DPPC) liposomes ...
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Article
Zn(II)-phthalocyanine as a photodynamic agent for tumours. II. Studies on the mechanism of photosensitised tumour necrosis
The mechanism of tumour necrosis photosensitised by liposome-delivered Zn(II) phthalocyanine (Zn-Pc) has been studied in mice bearing a transplanted MS-2 fibrosarcoma. Ultrastructural analyses of tumour specim...
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Article
Liposome- or LDL-administered Zn (II)-phthalocyanine as a photodynamic agent for tumours. I. Pharmacokinetic properties and phototherapeutic efficiency
The pharmacokinetics of Zn-phthalocyanine (Zn-Pc) in mice bearing a transplanted MS-2 fibrosarcoma has been studied using dipalmitoyl-phosphatidylcholine (DPPC) liposomes and low density lipoproteins (LDL) as ...
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Article
TIN-PROTOPORPHYRIN (Sn-pP) EFFECT ON HYPER- BILIRUBINEMIA DUE TO CRIGLER-NAJJAR DISEASE (CND) TYPE 1
CND is a rare disorder characterized by severe unconjugated hyperbilirubinemia appearing in the first days of life and persisting throughout life. We tried to control the hyperbilirubinemia in an infant with C...
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Article
Accumulation of zinc-phthalocyanine (Zn-Pc) in the aorta of atherosclerotic rabbits
Phthalocyanines are structural analogs of porphyrins and are characterized by a closely similar mechanism of transport in the bloodstream. We evaluated the accumulation of liposomebound Zn(II)-phthalocyanine (...
