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A Comparison of Laser and Arc-Lamp Spectroscopic Systems for In-Vivo Pharmacokinetic Measurements of Photosensitizers Used in Photodynamic Therapy

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Laser Systems for Photobiology and Photomedicine

Part of the book series: NATO ASI Series ((NSSB,volume 252))

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Abstract

The treatment of neoplastic tissue using photodynamic therapy is currently undergoing a worldwide concerted research effort, enabling human treatment of such tissue using the drug hematoporphyrin derivative (HPD), see for example1. Current research is centered on the development of new photosensitizers, new instrumentation for delivering the required radiant energy, an understanding of processes involved in the selective biodistribution of photosensitizers as well as the mechanism by which the induced cytotoxic reaction is produced.

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References

  1. “Photosensitizing Compounds: Their Chemistry, Biology and Clinical use”, Ciba Foundation Symposium 146, Wiley, Chichester (1989)

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  2. E. Reddi, G. Lo Castro, R. Biolo and G. Jori, “Pharmacokinetic studies with zinc (Il)-phtalocyanine in tumor bearing mice”, Br. J. Cancer, 56:597 (1987)

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  3. R. M. Pottier, Y. F. A. Chan, J.-P. LaPlante, T. G. Truscott, J. C. Kennedy and L. A. Beiner, “Non-invasive technique for obtaining fluorescence excitation and emission spectra in-vivo”, Photochem. Photobiol., 44:679 (1986)

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  4. R. M. Pottier and J. C. Kennedy, “Photodiode array fluorescence technique for measuring drug clearance rates in-vivo, J. Photochem. Photobiol., B3:135 (1989).

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Authors and Affiliations

  1. The Royal Military College, Kingston, Ontario, Canada

    D. A. Russell, P. Nadeau & R. H. Pottier

  2. University of Padova, Italy

    G. Jori & E. Reddi

Authors
  1. D. A. Russell
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  2. P. Nadeau
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  3. R. H. Pottier
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  4. G. Jori
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  5. E. Reddi
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Editor information

Editors and Affiliations

  1. Hughes Research Laboratories, Malibu, California, USA

    A. N. Chester

  2. The Second University of Rome, Rome, Italy

    S. Martellucci

  3. IROE-CNR, Florence, Italy

    A. M. Scheggi

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© 1991 Plenum Press, New York

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Russell, D.A., Nadeau, P., Pottier, R.H., Jori, G., Reddi, E. (1991). A Comparison of Laser and Arc-Lamp Spectroscopic Systems for In-Vivo Pharmacokinetic Measurements of Photosensitizers Used in Photodynamic Therapy. In: Chester, A.N., Martellucci, S., Scheggi, A.M. (eds) Laser Systems for Photobiology and Photomedicine. NATO ASI Series, vol 252. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7287-5_20

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  • DOI: https://doi.org/10.1007/978-1-4684-7287-5_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7289-9

  • Online ISBN: 978-1-4684-7287-5

  • eBook Packages: Springer Book Archive

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