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Article
Water household of the common carp,Cyprinus carpio, when submitted to an osmotic challenge, as determined by diffusion-weighted magnetic resonance imaging at 7 T
In vivo diffusion-weighted magnetic resonance imaging (MRI) was used to determine the effects of an osmotic challenge (1% NaCl) to a freshwater fish, the common carp (Cyprinus carpio). The imaged...
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Article
Effects of Sublethal Copper Exposure on Copper Accumulation, Food Consumption, Growth, Energy Stores, and Nucleic Acid Content in Common Carp
Juvenile common carp were exposed for 28 days to three different sublethal copper concentrations (0.20 μM, 0.55 μM, and 0.80 μM). Food consumption was monitored on a daily basis during the exposure period, w...
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Article
Open AccessTumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion
Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant si...
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Article
Open AccessDegree of tumour vascularity correlates with drug accumulation and tumour response upon TNF-α-based isolated hepatic perfusion
Isolated hepatic perfusion (IHP) with melphalan with or without tumour necrosis factor alpha (TNF-α) is currently performed in clinical trials in patients with hepatic metastases. Previous studies led to the hypo...
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Article
Open AccessEffect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11
Promising preclinical activity with agents blocking the function of vascular endothelial growth factor (VEGF) has been observed in various cancer types, especially with combination therapy. However, these drug...
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Article
Difluorodeoxyuridine plasma concentrations after low-dose gemcitabine during chemoradiation in head and neck cancer patients
The aim of this study was to investigate whether relevant plasma levels of dFdU could be detected during concurrent chemoradiation (CRT) with low doses of dFdC administered in patients with head and neck cance...
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Article
Gene expression profiling of giant cell tumor of bone reveals downregulation of extracellular matrix components decorin and lumican associated with lung metastasis
Giant cell tumor of bone (GCTB) displays worrisome clinical features such as local recurrence and occasionally metastatic disease which are unpredictable by morphology. Additional routinely usable biomarkers d...
